TY - JOUR

T1 - Comparison of Global Cerebral Blood Flow Measured by Phase-Contrast Mapping MRI with O-15-H2O Positron Emission Tomography

AU - Vestergaard, Mark Bitsch

AU - Lindberg, Ulrich

AU - Aachmann-Andersen, Niels Jacob

AU - Lisbjerg, Kristian

AU - Christensen, Soren Just

AU - Rasmussen, Peter

AU - Olsen, Niels Vidiendal

AU - Law, Ian

AU - Larsson, Henrik Bo Wiberg

AU - Henriksen, Otto Molby

PY - 2017

Y1 - 2017

N2 - PurposeTo compare mean global cerebral blood flow (CBF) measured by phase-contrast mapping magnetic resonance imaging (PCM MRI) and by 15O-H2O positron emission tomography (PET) in healthy subjects. PCM MRI is increasingly being used to measure mean global CBF, but has not been validated in vivo against an accepted reference technique.Materials and MethodsSame-day measurements of CBF by 15O-H2O PET and subsequently by PCM MRI were performed on 22 healthy young male volunteers. Global CBF by PET was determined by applying a one-tissue compartment model with measurement of the arterial input function. Flow was measured in the internal carotid and vertebral arteries by a noncardiac triggered PCM MRI sequence at 3T. The measured flow was normalized to total brain weight determined from a volume-segmented 3D T1-weighted anatomical MR-scan.ResultsMean CBF was 34.9 ± 3.4 mL/100 g/min measured by 15O-H2O PET and 57.0 ± 6.8 mL/100 g/min measured by PCM MRI. The measurements were highly correlated (P = 0.0008, R2 = 0.44), although values obtained by PCM MRI were higher compared to 15O-H2O PET (absolute and relative differences were 22.0 ± 5.2 mL/100 g/min and 63.4 ± 14.8%, respectively).ConclusionThis study confirms the use of PCM MRI for quantification of global CBF, but also that PCM MRI systematically yields higher values relative to 15O-H2O PET, probably related to methodological bias.

AB - PurposeTo compare mean global cerebral blood flow (CBF) measured by phase-contrast mapping magnetic resonance imaging (PCM MRI) and by 15O-H2O positron emission tomography (PET) in healthy subjects. PCM MRI is increasingly being used to measure mean global CBF, but has not been validated in vivo against an accepted reference technique.Materials and MethodsSame-day measurements of CBF by 15O-H2O PET and subsequently by PCM MRI were performed on 22 healthy young male volunteers. Global CBF by PET was determined by applying a one-tissue compartment model with measurement of the arterial input function. Flow was measured in the internal carotid and vertebral arteries by a noncardiac triggered PCM MRI sequence at 3T. The measured flow was normalized to total brain weight determined from a volume-segmented 3D T1-weighted anatomical MR-scan.ResultsMean CBF was 34.9 ± 3.4 mL/100 g/min measured by 15O-H2O PET and 57.0 ± 6.8 mL/100 g/min measured by PCM MRI. The measurements were highly correlated (P = 0.0008, R2 = 0.44), although values obtained by PCM MRI were higher compared to 15O-H2O PET (absolute and relative differences were 22.0 ± 5.2 mL/100 g/min and 63.4 ± 14.8%, respectively).ConclusionThis study confirms the use of PCM MRI for quantification of global CBF, but also that PCM MRI systematically yields higher values relative to 15O-H2O PET, probably related to methodological bias.

KW - cerebral blood flow

KW - phase-contrast mapping

KW - positron emission tomography

U2 - 10.1002/jmri.25442

DO - 10.1002/jmri.25442

M3 - Journal article

C2 - 27619317

VL - 45

SP - 692

EP - 699

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 3

ER -