Comparative pharmacokinetics and pharmacodynamics of lisinopril and enalapril, alone and in combination with propranolol
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Comparative pharmacokinetics and pharmacodynamics of lisinopril and enalapril, alone and in combination with propranolol. / Bendtsen, F; Henriksen, Jens Henrik Sahl.
In: Journal of Human Hypertension, Vol. 3 Suppl 1, 1989, p. 139-45.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Comparative pharmacokinetics and pharmacodynamics of lisinopril and enalapril, alone and in combination with propranolol
AU - Bendtsen, F
AU - Henriksen, Jens Henrik Sahl
N1 - Keywords: Adult; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Drug Interactions; Drug Therapy, Combination; Enalapril; Female; Heart Rate; Humans; Lisinopril; Male; Propranolol
PY - 1989
Y1 - 1989
N2 - In an open, crossover study, the pharmacokinetic and pharmacodynamic profiles of lisinopril and enalapril, administered alone and in combination with propranolol, were evaluated in 12 volunteers. The maximum serum concentration (Cmax) of lisinopril and time to reach maximum concentration (Tmax) were 64 +/- 16 ng/ml and 7.5 +/- 1.5 h, respectively. The area under the serum curve (AUC) was 916 +/- 239 h. ng/ml. The Cmax of enalaprilat (89 +/- 34 ng/ml) was greater than that of lisinopril whilst Tmax was shorter (4.3 +/- 1.7 h) and AUC smaller (718 +/- 17 h.ng/ml) (P less than 0.01). Renal clearance of drug 48 h post-dosing showed that enalaprilat (164 +/- 38 ml/min) was cleared from plasma significantly more rapidly than lisinopril (82 +/- 16 ml/min) (P less than 0.001). Mean supine blood pressure decreased significantly with all treatments, as did heart rate. No significant changes were observed in either the serum concentrations or the urinary outputs of these ACE inhibitors following combination with propranolol, apart from a greater variability of Cmax after addition of propranolol to enalapril compared with lisinopril in combination.
AB - In an open, crossover study, the pharmacokinetic and pharmacodynamic profiles of lisinopril and enalapril, administered alone and in combination with propranolol, were evaluated in 12 volunteers. The maximum serum concentration (Cmax) of lisinopril and time to reach maximum concentration (Tmax) were 64 +/- 16 ng/ml and 7.5 +/- 1.5 h, respectively. The area under the serum curve (AUC) was 916 +/- 239 h. ng/ml. The Cmax of enalaprilat (89 +/- 34 ng/ml) was greater than that of lisinopril whilst Tmax was shorter (4.3 +/- 1.7 h) and AUC smaller (718 +/- 17 h.ng/ml) (P less than 0.01). Renal clearance of drug 48 h post-dosing showed that enalaprilat (164 +/- 38 ml/min) was cleared from plasma significantly more rapidly than lisinopril (82 +/- 16 ml/min) (P less than 0.001). Mean supine blood pressure decreased significantly with all treatments, as did heart rate. No significant changes were observed in either the serum concentrations or the urinary outputs of these ACE inhibitors following combination with propranolol, apart from a greater variability of Cmax after addition of propranolol to enalapril compared with lisinopril in combination.
M3 - Journal article
C2 - 2550636
VL - 3 Suppl 1
SP - 139
EP - 145
JO - Journal of Human Hypertension
JF - Journal of Human Hypertension
SN - 0950-9240
ER -
ID: 18692649