Combinations of genetic variants associated with bipolar disorder
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Combinations of genetic variants associated with bipolar disorder. / Mellerup, Erling; Andreassen, Ole A.; Bennike, Bente; Dam, Henrik; Djurovic, Srdjan; Jorgensen, Martin Balslev; Kessing, Lars Vedel; Koefoed, Pernille; Melle, Ingrid; Mors, Ole; Moeller, Gert Lykke.
In: PLOS ONE, Vol. 12, No. 12, e0189739, 12.2017.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Combinations of genetic variants associated with bipolar disorder
AU - Mellerup, Erling
AU - Andreassen, Ole A.
AU - Bennike, Bente
AU - Dam, Henrik
AU - Djurovic, Srdjan
AU - Jorgensen, Martin Balslev
AU - Kessing, Lars Vedel
AU - Koefoed, Pernille
AU - Melle, Ingrid
AU - Mors, Ole
AU - Moeller, Gert Lykke
PY - 2017/12
Y1 - 2017/12
N2 - The main objective of the study was to find genetic variants that in combination are significantly associated with bipolar disorder. In previous studies of bipolar disorder, combinations of three and four single nucleotide polymorphisms (SNP) genotypes taken from 803 SNPs were analyzed, and five clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of ten SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the five previous clusters were identified in the genomes of 266 or 44% of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome.The SNP genotypes in the smaller combinations were the normal homozygote, heterozygote or variant homozygote. In the combinations containing 10 SNP genotypes almost all the genotypes were the normal homozygote. Such a finding may indicate that accumulation in the genome of combinations containing few SNP genotypes may be a risk factor for bipolar disorder when those combinations contain relatively many rare SNP genotypes, whereas combinations need to contain many SNP genotypes to be a risk factor when most of the SNP genotypes are the normal homozygote.
AB - The main objective of the study was to find genetic variants that in combination are significantly associated with bipolar disorder. In previous studies of bipolar disorder, combinations of three and four single nucleotide polymorphisms (SNP) genotypes taken from 803 SNPs were analyzed, and five clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of ten SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the five previous clusters were identified in the genomes of 266 or 44% of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome.The SNP genotypes in the smaller combinations were the normal homozygote, heterozygote or variant homozygote. In the combinations containing 10 SNP genotypes almost all the genotypes were the normal homozygote. Such a finding may indicate that accumulation in the genome of combinations containing few SNP genotypes may be a risk factor for bipolar disorder when those combinations contain relatively many rare SNP genotypes, whereas combinations need to contain many SNP genotypes to be a risk factor when most of the SNP genotypes are the normal homozygote.
U2 - 10.1371/journal.pone.0189739
DO - 10.1371/journal.pone.0189739
M3 - Journal article
C2 - 29267373
AN - SCOPUS:85038953153
VL - 12
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 12
M1 - e0189739
ER -
ID: 188712172