Clinical pattern of severe Plasmodium falciparum malaria in Sudan in an area characterized by seasonal and unstable malaria transmission
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Clinical pattern of severe Plasmodium falciparum malaria in Sudan in an area characterized by seasonal and unstable malaria transmission. / Giha, H A; Elghazali, G; A-Elgadir, T M E; A-Elbasit, I E; Eltahir, E M; Baraka, O Z; Khier, M M; Adam, I; Troye-Blomberg, M; Theander, T G; Elbashir, M I.
In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 99, No. 4, 2005, p. 243-51.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Clinical pattern of severe Plasmodium falciparum malaria in Sudan in an area characterized by seasonal and unstable malaria transmission
AU - Giha, H A
AU - Elghazali, G
AU - A-Elgadir, T M E
AU - A-Elbasit, I E
AU - Eltahir, E M
AU - Baraka, O Z
AU - Khier, M M
AU - Adam, I
AU - Troye-Blomberg, M
AU - Theander, T G
AU - Elbashir, M I
N1 - Keywords: Acute Disease; Adolescent; Adult; Age Distribution; Anemia; Child; Child, Preschool; Endemic Diseases; Female; Humans; Hypotension; Infant; Malaria, Cerebral; Malaria, Falciparum; Male; Seasons; Seizures; Severity of Illness Index; Sudan
PY - 2005
Y1 - 2005
N2 - A hospital-based study was carried out in Gedarif town, eastern Sudan, an area of markedly unstable malaria transmission. Among the 2488 diagnosed malaria patients, 4.4% fulfilled the WHO criteria for severe malaria, and seven died of cerebral malaria. The predominant complication was severe malarial anemia (45.4%), followed by convulsions (21%), cerebral malaria (16. 4%) and hypotension (11.8%). Severe malaria was recognized in all age groups, but 44.5% of patients were aged 2 to 4 years. The mean ages of patients with severe anemia (5.6 years) and convulsions (5.9 years) were significantly lower than the mean ages of patients with cerebral malaria (14.1 years) or hypotension (35.2 years). Patients with convulsions and cerebral malaria had significantly higher mean parasite count (69972 and 56110 parasites/microL, respectively) than patients with severe anemia (24637 parasites/microL) or hypotension (13667 parasites/microL). The mean blood glucose level was higher in patients with cerebral malaria than in patients with anemia, and higher in patients who died than in patients who survived. In this setting, the clinico-epidemiological pattern of severe malaria varies considerably from that of hyperendemic regions in sub-Saharan Africa, and there is considerable variation between the individual complications of severe malaria.
AB - A hospital-based study was carried out in Gedarif town, eastern Sudan, an area of markedly unstable malaria transmission. Among the 2488 diagnosed malaria patients, 4.4% fulfilled the WHO criteria for severe malaria, and seven died of cerebral malaria. The predominant complication was severe malarial anemia (45.4%), followed by convulsions (21%), cerebral malaria (16. 4%) and hypotension (11.8%). Severe malaria was recognized in all age groups, but 44.5% of patients were aged 2 to 4 years. The mean ages of patients with severe anemia (5.6 years) and convulsions (5.9 years) were significantly lower than the mean ages of patients with cerebral malaria (14.1 years) or hypotension (35.2 years). Patients with convulsions and cerebral malaria had significantly higher mean parasite count (69972 and 56110 parasites/microL, respectively) than patients with severe anemia (24637 parasites/microL) or hypotension (13667 parasites/microL). The mean blood glucose level was higher in patients with cerebral malaria than in patients with anemia, and higher in patients who died than in patients who survived. In this setting, the clinico-epidemiological pattern of severe malaria varies considerably from that of hyperendemic regions in sub-Saharan Africa, and there is considerable variation between the individual complications of severe malaria.
U2 - 10.1016/j.trstmh.2004.04.002
DO - 10.1016/j.trstmh.2004.04.002
M3 - Journal article
C2 - 15708383
VL - 99
SP - 243
EP - 251
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
SN - 0035-9203
IS - 4
ER -
ID: 6765342