Clinical impact of vital sign abnormalities in patients admitted with acute exacerbation of chronic obstructive pulmonary disease: an observational study using continuous wireless monitoring
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Clinical impact of vital sign abnormalities in patients admitted with acute exacerbation of chronic obstructive pulmonary disease : an observational study using continuous wireless monitoring. / Elvekjaer, Mikkel; Rasmussen, Søren M.; Grønbæk, Katja K.; Porsbjerg, Celeste M.; Jensen, Jens Ulrik; Haahr-Raunkjær, Camilla; Mølgaard, Jesper; Søgaard, Marlene; Sørensen, Helge B. D.; Aasvang, Eske K.; Meyhoff, Christian S.
In: Internal and Emergency Medicine, Vol. 17, No. 6, 2022, p. 1689–1698.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Clinical impact of vital sign abnormalities in patients admitted with acute exacerbation of chronic obstructive pulmonary disease
T2 - an observational study using continuous wireless monitoring
AU - Elvekjaer, Mikkel
AU - Rasmussen, Søren M.
AU - Grønbæk, Katja K.
AU - Porsbjerg, Celeste M.
AU - Jensen, Jens Ulrik
AU - Haahr-Raunkjær, Camilla
AU - Mølgaard, Jesper
AU - Søgaard, Marlene
AU - Sørensen, Helge B. D.
AU - Aasvang, Eske K.
AU - Meyhoff, Christian S.
N1 - Publisher Copyright: © 2022, The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI).
PY - 2022
Y1 - 2022
N2 - Early detection of abnormal vital signs is critical for timely management of acute hospitalised patients and continuous monitoring may improve this. We aimed to assess the association between preceding vital sign abnormalities and serious adverse events (SAE) in patients hospitalised with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Two hundred patients’ vital signs were wirelessly and continuously monitored with peripheral oxygen saturation, heart rate, and respiratory rate during the first 4 days after admission for AECOPD. Non-invasive blood pressure was also measured every 30–60 min. The primary outcome was occurrence of SAE according to international definitions within 30 days and physiological data were analysed for preceding vital sign abnormalities. Data were presented as the mean cumulative duration of vital sign abnormalities per 24 h and analysed using Wilcoxon rank sum test. SAE during ongoing continuous monitoring occurred in 50 patients (25%). Patients suffering SAE during the monitoring period had on average 455 min (SD 413) per 24 h of any preceding vital sign abnormality versus 292 min (SD 246) in patients without SAE, p = 0.08, mean difference 163 min [95% CI 61–265]. Mean duration of bradypnea (respiratory rate < 11 min−1) was 48 min (SD 173) compared with 30 min (SD 84) in patients without SAE, p = 0.01. In conclusion, the duration of physiological abnormalities was substantial in patients with AECOPD. There were no statistically significant differences between patients with and without SAE in the overall duration of preceding physiological abnormalities. Study registration: http://ClinicalTrials.gov (NCT03660501). Date of registration: Sept 6 2018.
AB - Early detection of abnormal vital signs is critical for timely management of acute hospitalised patients and continuous monitoring may improve this. We aimed to assess the association between preceding vital sign abnormalities and serious adverse events (SAE) in patients hospitalised with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Two hundred patients’ vital signs were wirelessly and continuously monitored with peripheral oxygen saturation, heart rate, and respiratory rate during the first 4 days after admission for AECOPD. Non-invasive blood pressure was also measured every 30–60 min. The primary outcome was occurrence of SAE according to international definitions within 30 days and physiological data were analysed for preceding vital sign abnormalities. Data were presented as the mean cumulative duration of vital sign abnormalities per 24 h and analysed using Wilcoxon rank sum test. SAE during ongoing continuous monitoring occurred in 50 patients (25%). Patients suffering SAE during the monitoring period had on average 455 min (SD 413) per 24 h of any preceding vital sign abnormality versus 292 min (SD 246) in patients without SAE, p = 0.08, mean difference 163 min [95% CI 61–265]. Mean duration of bradypnea (respiratory rate < 11 min−1) was 48 min (SD 173) compared with 30 min (SD 84) in patients without SAE, p = 0.01. In conclusion, the duration of physiological abnormalities was substantial in patients with AECOPD. There were no statistically significant differences between patients with and without SAE in the overall duration of preceding physiological abnormalities. Study registration: http://ClinicalTrials.gov (NCT03660501). Date of registration: Sept 6 2018.
KW - Acute exacerbation of chronic obstructive pulmonary disease
KW - Clinical deterioration
KW - Monitoring
KW - Outcome
KW - Vital signs/physiology
KW - Wireless technology
U2 - 10.1007/s11739-022-02988-w
DO - 10.1007/s11739-022-02988-w
M3 - Journal article
C2 - 35593967
AN - SCOPUS:85130243196
VL - 17
SP - 1689
EP - 1698
JO - Internal and Emergency Medicine
JF - Internal and Emergency Medicine
SN - 1828-0447
IS - 6
ER -
ID: 320016370