Clinical correlates of weight loss and attrition during a 10-week dietary intervention study: Results from the NUGENOB project
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Clinical correlates of weight loss and attrition during a 10-week dietary intervention study : Results from the NUGENOB project. / Handjieva-Darlenska, Teodora; Holst, Claus; Grau, Katrine; Blaak, Ellen; Martinez, J Alfredo; Oppert, Jean-Michel; Taylor, Moira A; Sørensen, Thorkild I.A.; Astrup, Arne.
In: Obesity Facts, Vol. 5, No. 6, 2012, p. 928-936.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Clinical correlates of weight loss and attrition during a 10-week dietary intervention study
T2 - Results from the NUGENOB project
AU - Handjieva-Darlenska, Teodora
AU - Holst, Claus
AU - Grau, Katrine
AU - Blaak, Ellen
AU - Martinez, J Alfredo
AU - Oppert, Jean-Michel
AU - Taylor, Moira A
AU - Sørensen, Thorkild I.A.
AU - Astrup, Arne
N1 - IHE 2012 033
PY - 2012
Y1 - 2012
N2 - Objective: The aim of this study was to identify the pre-treatment subject characteristics and weight loss changes as determinants of weight loss and attrition during a 10-week dietary intervention study. Methods: A total of 771 obese subjects (BMI 35.6 kg/m(2)) of both genders were included from 8 clinical centres in 7 European countries, who underwent a 10-week dietary intervention study comparing two hypo-energetic (-600 kcal/day) diets varying in fat content. Results: The multiple regression model showed that weight loss at week 10 was predicted by: 6.55 + 1.27 × early weight loss (kg) at week 1 + 1.35 × gender (R(2) = 0.28, p <0.001). When performing the corresponding model with half-way weight loss (week 5) as covariate, the regression equation was: weight loss (kg) at week 10 = 1.88 + 1.38 × half-way weight loss (kg) (week 5) + 0.42 × gender (R(2) = 0.77, p <0.001). A cut-off target of = 4 kg weight loss at week 5 emerged as an optimal predictor for reaching at least 10% weight loss at week 10. Greater attrition likelihood was predicted by high-fat diet, decreased early and half-way weight losses. Conclusion: Early and half-way weight losses are associated with and could contribute to prediction of the final weight loss and attrition. Copyright © 2012 S. Karger GmbH, Freiburg.
AB - Objective: The aim of this study was to identify the pre-treatment subject characteristics and weight loss changes as determinants of weight loss and attrition during a 10-week dietary intervention study. Methods: A total of 771 obese subjects (BMI 35.6 kg/m(2)) of both genders were included from 8 clinical centres in 7 European countries, who underwent a 10-week dietary intervention study comparing two hypo-energetic (-600 kcal/day) diets varying in fat content. Results: The multiple regression model showed that weight loss at week 10 was predicted by: 6.55 + 1.27 × early weight loss (kg) at week 1 + 1.35 × gender (R(2) = 0.28, p <0.001). When performing the corresponding model with half-way weight loss (week 5) as covariate, the regression equation was: weight loss (kg) at week 10 = 1.88 + 1.38 × half-way weight loss (kg) (week 5) + 0.42 × gender (R(2) = 0.77, p <0.001). A cut-off target of = 4 kg weight loss at week 5 emerged as an optimal predictor for reaching at least 10% weight loss at week 10. Greater attrition likelihood was predicted by high-fat diet, decreased early and half-way weight losses. Conclusion: Early and half-way weight losses are associated with and could contribute to prediction of the final weight loss and attrition. Copyright © 2012 S. Karger GmbH, Freiburg.
U2 - 10.1159/000345951
DO - 10.1159/000345951
M3 - Journal article
C2 - 23296282
VL - 5
SP - 928
EP - 936
JO - Obesity Facts
JF - Obesity Facts
SN - 1662-4025
IS - 6
ER -
ID: 44213271