Chromatin dynamics in genome stability: Roles in suppressing endogenous DNA damage and facilitating DNA repair

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Genomic DNA is compacted into chromatin through packaging with histone and non-histone proteins. Importantly, DNA accessibility is dynamically regulated to ensure genome stability. This is exemplified in the response to DNA damage where chromatin relaxation near genomic lesions serves to promote access of relevant enzymes to specific DNA regions for signaling and repair. Furthermore, recent data highlight genome maintenance roles of chromatin through the regulation of endogenous DNA-templated processes including transcription and replication. Here, we review research that shows the importance of chromatin structure regulation in maintaining genome integrity by multiple mechanisms including facilitating DNA repair and directly suppressing endogenous DNA damage.

Original languageEnglish
Article number1486
JournalInternational Journal of Molecular Sciences
Issue number7
Number of pages21
Publication statusPublished - 10 Jul 2017

    Research areas

  • Chromatin, DNA damage response, Endogenous DNA damage, Genome maintenance

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