Cholecystokinin expression in tumors: biogenetic and diagnostic implications
Research output: Contribution to journal › Review › Research › peer-review
Cholecystokinin (CCK) is a classic gut hormone. CCK is also a complex system of peptides expressed in several molecular forms in enteroendocrine I cells, in cerebral and peripheral neurons, in cardiac myocytes and spermatozoa. CCK gene expression has now been found at protein or peptide level in different neuroendocrine tumors; cerebral gliomas and astrocytomas and specific pediatric tumors. Tumor hypersecretion of CCK was recently reported in a patient with a metastatic islet cell tumor and hypercholecystokininemia resulting in a novel tumor syndrome, the cholecystokininoma syndrome. This review presents an overview of the cell-specific biogenesis of CCK peptides, and a description of the CCK expression in tumors and of the cholecystokininoma syndrome. Finally, assays for the diagnosis of CCK-producing tumors are reviewed.
Original language | English |
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Journal | Future Oncology |
Volume | 12 |
Issue number | 18 |
Pages (from-to) | 2135-47 |
Number of pages | 13 |
ISSN | 1479-6694 |
DOIs | |
Publication status | Published - Sep 2016 |
- Biomarkers, Tumor, Cell Proliferation, Cholecystokinin, Gene Expression Regulation, Neoplastic, Humans, Multigene Family, Neoplasms, Prognosis, Protein Binding, Protein Processing, Post-Translational, Protein Transport, RNA, Messenger, Receptors, Cholecystokinin, Journal Article, Review
Research areas
ID: 176826933