Cholecystokinin and the hormone concept
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- [20493614 - Endocrine Connections] Cholecystokinin and the hormone concept
Final published version, 1.1 MB, PDF document
The birth certificate for endocrinology was Bayliss’ and Starling’s demonstration in 1902 that regulation of bodily functions is not only neuronal but also due to blood-borne messengers. Starling named these messengers hormones. Since then transport via blood has defined hormones. This definition, however, may be too narrow. Thus, today we know that several peptide hormones are not only produced and released to blood from endocrine cells but also released from neurons, myocytes, immune cells, endothelial cells, spermatogenic cells, fat cells, etc. And they are often secreted in cell-specific molecular forms with more or less different spectra of activity. The present review depicts this development with the story about cholecystokinin which was discovered in 1928 as a hormone and still in 1976 was conceived as a single blood-borne peptide. Today’s multifaceted picture of cholecystokinin suggests that time may be ripe for expansion of the hormone concept to all messenger molecules, which activate their target cells – irrespective of their road to the target (endocrine, neurocrine, neuronal, paracrine, autocrine, etc.) and irrespective of their kind of activity as classical hormone, growth factorneurotransmitter, adipokine, cytokine, myokine, or fertility factor.
Original language | English |
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Journal | Endocrine Connections |
Volume | 10 |
Issue number | 3 |
Pages (from-to) | R139-R150 |
Number of pages | 12 |
ISSN | 2049-3614 |
DOIs | |
Publication status | Published - 2021 |
Bibliographical note
Funding Information:
The author wishes to thank Connie Bundgaard (MA) for excellent and patient help in the writing of this review. The CCK research in the laboratory of the author was initiated fifty years ago, and has been supported by the Danish Medical Research Council, the Danish Cancer Union, the Novo Nordic Foundation, the Lundbeck Foundation, and the State Biotechnology ‘Center for Cellular Communication’.
Funding Information:
The author wishes to thank Connie Bundgaard (MA) for excellent and patient help in the writing of this review. The CCK research in the laboratory of the author was initiated fifty years ago, and has been supported by the Danish Medical Research Council, the Danish Cancer Union, the Novo Nordic Foundation, the Lundbeck Foundation, and the State Biotechnology ?Center for Cellular Communication?.
Publisher Copyright:
© 2021 The authors.
- Bioactive peptides, Cholecystokinin, Growth factors, Hormone concept, Neurotransmitter peptides
Research areas
ID: 282194732