Childhood height, adult height, and the risk of prostate cancer
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Childhood height, adult height, and the risk of prostate cancer. / Bjerregaard, Lise Geisler; Aarestrup, Julie; Gamborg, Michael; Lange, Theis; Tjønneland, Anne; Baker, Jennifer L.
In: Cancer Causes & Control, Vol. 27, No. 4, 04.2016, p. 561-567.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Childhood height, adult height, and the risk of prostate cancer
AU - Bjerregaard, Lise Geisler
AU - Aarestrup, Julie
AU - Gamborg, Michael
AU - Lange, Theis
AU - Tjønneland, Anne
AU - Baker, Jennifer L
PY - 2016/4
Y1 - 2016/4
N2 - PURPOSE: We previously showed that childhood height is positively associated with prostate cancer risk. It is, however, unknown whether childhood height exerts its effects independently of or through adult height. We investigated whether and to what extent childhood height has a direct effect on the risk of prostate cancer apart from adult height.METHODS: We included 5,871 men with height measured at ages 7 and 13 years in the Copenhagen School Health Records Register who also had adult (50-65 years) height measured in the Danish Diet, Cancer and Health study. Prostate cancer status was obtained through linkage to the Danish Cancer Registry. Direct and total effects of childhood height on prostate cancer risk were estimated from Cox regressions.RESULTS: From 1996 to 2012, 429 prostate cancers occurred. Child and adult heights were positively and significantly associated with prostate cancer risk. When adjusted for adult height, height at age 7 years was no longer significantly associated with the risk of prostate cancer. Height at 13 years was significantly and positively associated with prostate cancer risk even when adult height was adjusted for; per height z-score the hazard ratio was 1.15 [95 % confidence interval (CI) 1.01-1.32].CONCLUSIONS: The effect of height at 13 years on the risk of prostate cancer was not entirely mediated through adult height, suggesting that child height and adult height may be associated with prostate cancer through different pathways.
AB - PURPOSE: We previously showed that childhood height is positively associated with prostate cancer risk. It is, however, unknown whether childhood height exerts its effects independently of or through adult height. We investigated whether and to what extent childhood height has a direct effect on the risk of prostate cancer apart from adult height.METHODS: We included 5,871 men with height measured at ages 7 and 13 years in the Copenhagen School Health Records Register who also had adult (50-65 years) height measured in the Danish Diet, Cancer and Health study. Prostate cancer status was obtained through linkage to the Danish Cancer Registry. Direct and total effects of childhood height on prostate cancer risk were estimated from Cox regressions.RESULTS: From 1996 to 2012, 429 prostate cancers occurred. Child and adult heights were positively and significantly associated with prostate cancer risk. When adjusted for adult height, height at age 7 years was no longer significantly associated with the risk of prostate cancer. Height at 13 years was significantly and positively associated with prostate cancer risk even when adult height was adjusted for; per height z-score the hazard ratio was 1.15 [95 % confidence interval (CI) 1.01-1.32].CONCLUSIONS: The effect of height at 13 years on the risk of prostate cancer was not entirely mediated through adult height, suggesting that child height and adult height may be associated with prostate cancer through different pathways.
U2 - 10.1007/s10552-016-0731-8
DO - 10.1007/s10552-016-0731-8
M3 - Journal article
C2 - 26951518
VL - 27
SP - 561
EP - 567
JO - Cancer Causes & Control
JF - Cancer Causes & Control
SN - 0957-5243
IS - 4
ER -
ID: 159743765