Characterization of upper thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in diabetic rats

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Characterization of upper thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in diabetic rats. / Ghorbani, Marie Louise M; Qin, Chao; Wu, Mingyuan; Farber, Jay P; Sheykhzade, Majid; Fjalland, Bjarne; Nyborg, Niels C B; Foreman, Robert D.

In: Autonomic Neuroscience: Basic and Clinical, Vol. 165, No. 2, 07.12.2011, p. 168-177.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ghorbani, MLM, Qin, C, Wu, M, Farber, JP, Sheykhzade, M, Fjalland, B, Nyborg, NCB & Foreman, RD 2011, 'Characterization of upper thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in diabetic rats', Autonomic Neuroscience: Basic and Clinical, vol. 165, no. 2, pp. 168-177. https://doi.org/10.1016/j.autneu.2011.07.007

APA

Ghorbani, M. L. M., Qin, C., Wu, M., Farber, J. P., Sheykhzade, M., Fjalland, B., Nyborg, N. C. B., & Foreman, R. D. (2011). Characterization of upper thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in diabetic rats. Autonomic Neuroscience: Basic and Clinical, 165(2), 168-177. https://doi.org/10.1016/j.autneu.2011.07.007

Vancouver

Ghorbani MLM, Qin C, Wu M, Farber JP, Sheykhzade M, Fjalland B et al. Characterization of upper thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in diabetic rats. Autonomic Neuroscience: Basic and Clinical. 2011 Dec 7;165(2):168-177. https://doi.org/10.1016/j.autneu.2011.07.007

Author

Ghorbani, Marie Louise M ; Qin, Chao ; Wu, Mingyuan ; Farber, Jay P ; Sheykhzade, Majid ; Fjalland, Bjarne ; Nyborg, Niels C B ; Foreman, Robert D. / Characterization of upper thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in diabetic rats. In: Autonomic Neuroscience: Basic and Clinical. 2011 ; Vol. 165, No. 2. pp. 168-177.

Bibtex

@article{5800d13785294f2390d0fe766a9a729b,
title = "Characterization of upper thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in diabetic rats",
abstract = "The aim of the present study was to examine spinal processing of cardiac and somatic nociceptive input in rats with STZ-induced diabetes. Type 1 diabetes was induced with streptozotocin (50mg/kg) in 14 male Sprague-Dawley rats and citrate buffer was injected in 14 control rats. After 4-11weeks, the rats were anesthetized with pentobarbital, ventilated and paralyzed. A laminectomy enabled extracellular recording of T(3) spinal cord neuronal activity. Intrapericardial administration of a mixture of algogenic chemicals (bradykinin, serotonin, prostaglandin E(2) (all at 10(-5)M), and adenosine (10(-3)M)) was applied to activate nociceptors of cardiac afferent nerve endings. Furthermore, somatic receptive properties were examined by applying innocuous (brush and light pressure) and noxious (pinch) cutaneous mechanical stimuli. Diabetes-induced increases in spontaneous activity were observed in subsets of neurons exhibiting long-lasting excitatory responses to administration of the algogenic mixture. Algogenic chemicals altered activity of a larger proportion of neurons from diabetic animals (73/111) than control animals (55/115, P",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Ghorbani, {Marie Louise M} and Chao Qin and Mingyuan Wu and Farber, {Jay P} and Majid Sheykhzade and Bjarne Fjalland and Nyborg, {Niels C B} and Foreman, {Robert D}",
note = "Copyright {\textcopyright} 2011 Elsevier B.V. All rights reserved.",
year = "2011",
month = dec,
day = "7",
doi = "10.1016/j.autneu.2011.07.007",
language = "English",
volume = "165",
pages = "168--177",
journal = "Autonomic Neuroscience: Basic and Clinical",
issn = "1566-0702",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Characterization of upper thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in diabetic rats

AU - Ghorbani, Marie Louise M

AU - Qin, Chao

AU - Wu, Mingyuan

AU - Farber, Jay P

AU - Sheykhzade, Majid

AU - Fjalland, Bjarne

AU - Nyborg, Niels C B

AU - Foreman, Robert D

N1 - Copyright © 2011 Elsevier B.V. All rights reserved.

PY - 2011/12/7

Y1 - 2011/12/7

N2 - The aim of the present study was to examine spinal processing of cardiac and somatic nociceptive input in rats with STZ-induced diabetes. Type 1 diabetes was induced with streptozotocin (50mg/kg) in 14 male Sprague-Dawley rats and citrate buffer was injected in 14 control rats. After 4-11weeks, the rats were anesthetized with pentobarbital, ventilated and paralyzed. A laminectomy enabled extracellular recording of T(3) spinal cord neuronal activity. Intrapericardial administration of a mixture of algogenic chemicals (bradykinin, serotonin, prostaglandin E(2) (all at 10(-5)M), and adenosine (10(-3)M)) was applied to activate nociceptors of cardiac afferent nerve endings. Furthermore, somatic receptive properties were examined by applying innocuous (brush and light pressure) and noxious (pinch) cutaneous mechanical stimuli. Diabetes-induced increases in spontaneous activity were observed in subsets of neurons exhibiting long-lasting excitatory responses to administration of the algogenic mixture. Algogenic chemicals altered activity of a larger proportion of neurons from diabetic animals (73/111) than control animals (55/115, P

AB - The aim of the present study was to examine spinal processing of cardiac and somatic nociceptive input in rats with STZ-induced diabetes. Type 1 diabetes was induced with streptozotocin (50mg/kg) in 14 male Sprague-Dawley rats and citrate buffer was injected in 14 control rats. After 4-11weeks, the rats were anesthetized with pentobarbital, ventilated and paralyzed. A laminectomy enabled extracellular recording of T(3) spinal cord neuronal activity. Intrapericardial administration of a mixture of algogenic chemicals (bradykinin, serotonin, prostaglandin E(2) (all at 10(-5)M), and adenosine (10(-3)M)) was applied to activate nociceptors of cardiac afferent nerve endings. Furthermore, somatic receptive properties were examined by applying innocuous (brush and light pressure) and noxious (pinch) cutaneous mechanical stimuli. Diabetes-induced increases in spontaneous activity were observed in subsets of neurons exhibiting long-lasting excitatory responses to administration of the algogenic mixture. Algogenic chemicals altered activity of a larger proportion of neurons from diabetic animals (73/111) than control animals (55/115, P

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1016/j.autneu.2011.07.007

DO - 10.1016/j.autneu.2011.07.007

M3 - Journal article

C2 - 21862419

VL - 165

SP - 168

EP - 177

JO - Autonomic Neuroscience: Basic and Clinical

JF - Autonomic Neuroscience: Basic and Clinical

SN - 1566-0702

IS - 2

ER -

ID: 33968861