Characterization of temperature-induced phase transitions in five polymorphic forms of sulfathiazole by terahertz pulsed spectroscopy and differential scanning calorimetry

Research output: Contribution to journalJournal articlepeer-review

Standard

Characterization of temperature-induced phase transitions in five polymorphic forms of sulfathiazole by terahertz pulsed spectroscopy and differential scanning calorimetry. / Zeitler, J Axel; Newnham, David A; Taday, Philip F; Threlfall, Terry L; Lancaster, Robert W; Berg, Rolf W.; Strachan, Clare J; Pepper, Michael; Gordon, Keith C; Rades, Thomas.

In: Journal of Pharmaceutical Sciences, Vol. 95, No. 11, 2006, p. 2486-98.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Zeitler, JA, Newnham, DA, Taday, PF, Threlfall, TL, Lancaster, RW, Berg, RW, Strachan, CJ, Pepper, M, Gordon, KC & Rades, T 2006, 'Characterization of temperature-induced phase transitions in five polymorphic forms of sulfathiazole by terahertz pulsed spectroscopy and differential scanning calorimetry', Journal of Pharmaceutical Sciences, vol. 95, no. 11, pp. 2486-98. https://doi.org/10.1002/jps.20719

APA

Zeitler, J. A., Newnham, D. A., Taday, P. F., Threlfall, T. L., Lancaster, R. W., Berg, R. W., Strachan, C. J., Pepper, M., Gordon, K. C., & Rades, T. (2006). Characterization of temperature-induced phase transitions in five polymorphic forms of sulfathiazole by terahertz pulsed spectroscopy and differential scanning calorimetry. Journal of Pharmaceutical Sciences, 95(11), 2486-98. https://doi.org/10.1002/jps.20719

Vancouver

Zeitler JA, Newnham DA, Taday PF, Threlfall TL, Lancaster RW, Berg RW et al. Characterization of temperature-induced phase transitions in five polymorphic forms of sulfathiazole by terahertz pulsed spectroscopy and differential scanning calorimetry. Journal of Pharmaceutical Sciences. 2006;95(11):2486-98. https://doi.org/10.1002/jps.20719

Author

Zeitler, J Axel ; Newnham, David A ; Taday, Philip F ; Threlfall, Terry L ; Lancaster, Robert W ; Berg, Rolf W. ; Strachan, Clare J ; Pepper, Michael ; Gordon, Keith C ; Rades, Thomas. / Characterization of temperature-induced phase transitions in five polymorphic forms of sulfathiazole by terahertz pulsed spectroscopy and differential scanning calorimetry. In: Journal of Pharmaceutical Sciences. 2006 ; Vol. 95, No. 11. pp. 2486-98.

Bibtex

@article{00938ec8a7c5485d910ab018e5f5a8fe,
title = "Characterization of temperature-induced phase transitions in five polymorphic forms of sulfathiazole by terahertz pulsed spectroscopy and differential scanning calorimetry",
abstract = "The far-infrared properties of all five known polymorphic forms of the drug sulfathiazole have been studied by terahertz pulsed spectroscopy and low-frequency Raman spectroscopy. The observed spectra of the different polymorphs are distinctly different. Terahertz pulsed spectroscopy proves to be a rapid and complementary alternative to other physical characterization techniques reported in the literature for distinguishing between the five forms. Variable-temperature measurements (293-473 K) of all polymorphic forms have been performed. The phase transitions observed have been related to thermal analysis data. Form I is the form stable at high temperature of sulfathiazole with a melting point of about 475 K. Form II melts at around 470 K and recrystallizes at higher temperatures to form I. Forms III, IV, and V all convert to form I via a solid-solid phase transition at temperatures below 450 K. The phase transitions can be monitored by terahertz pulsed spectroscopy. Polymorphic impurities of the samples can be detected in the room temperature spectra and their effect on the phase transition behavior can be studied.",
author = "Zeitler, {J Axel} and Newnham, {David A} and Taday, {Philip F} and Threlfall, {Terry L} and Lancaster, {Robert W} and Berg, {Rolf W.} and Strachan, {Clare J} and Michael Pepper and Gordon, {Keith C} and Thomas Rades",
note = "Copyright 2006 Wiley-Liss, Inc. and the American Pharmacists Association",
year = "2006",
doi = "10.1002/jps.20719",
language = "English",
volume = "95",
pages = "2486--98",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "11",

}

RIS

TY - JOUR

T1 - Characterization of temperature-induced phase transitions in five polymorphic forms of sulfathiazole by terahertz pulsed spectroscopy and differential scanning calorimetry

AU - Zeitler, J Axel

AU - Newnham, David A

AU - Taday, Philip F

AU - Threlfall, Terry L

AU - Lancaster, Robert W

AU - Berg, Rolf W.

AU - Strachan, Clare J

AU - Pepper, Michael

AU - Gordon, Keith C

AU - Rades, Thomas

N1 - Copyright 2006 Wiley-Liss, Inc. and the American Pharmacists Association

PY - 2006

Y1 - 2006

N2 - The far-infrared properties of all five known polymorphic forms of the drug sulfathiazole have been studied by terahertz pulsed spectroscopy and low-frequency Raman spectroscopy. The observed spectra of the different polymorphs are distinctly different. Terahertz pulsed spectroscopy proves to be a rapid and complementary alternative to other physical characterization techniques reported in the literature for distinguishing between the five forms. Variable-temperature measurements (293-473 K) of all polymorphic forms have been performed. The phase transitions observed have been related to thermal analysis data. Form I is the form stable at high temperature of sulfathiazole with a melting point of about 475 K. Form II melts at around 470 K and recrystallizes at higher temperatures to form I. Forms III, IV, and V all convert to form I via a solid-solid phase transition at temperatures below 450 K. The phase transitions can be monitored by terahertz pulsed spectroscopy. Polymorphic impurities of the samples can be detected in the room temperature spectra and their effect on the phase transition behavior can be studied.

AB - The far-infrared properties of all five known polymorphic forms of the drug sulfathiazole have been studied by terahertz pulsed spectroscopy and low-frequency Raman spectroscopy. The observed spectra of the different polymorphs are distinctly different. Terahertz pulsed spectroscopy proves to be a rapid and complementary alternative to other physical characterization techniques reported in the literature for distinguishing between the five forms. Variable-temperature measurements (293-473 K) of all polymorphic forms have been performed. The phase transitions observed have been related to thermal analysis data. Form I is the form stable at high temperature of sulfathiazole with a melting point of about 475 K. Form II melts at around 470 K and recrystallizes at higher temperatures to form I. Forms III, IV, and V all convert to form I via a solid-solid phase transition at temperatures below 450 K. The phase transitions can be monitored by terahertz pulsed spectroscopy. Polymorphic impurities of the samples can be detected in the room temperature spectra and their effect on the phase transition behavior can be studied.

U2 - 10.1002/jps.20719

DO - 10.1002/jps.20719

M3 - Journal article

C2 - 16892211

VL - 95

SP - 2486

EP - 2498

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 11

ER -

ID: 40357381