Changes in inflammatory and coagulation biomarkers: a randomized comparison of immediate versus deferred antiretroviral therapy in patients with HIV infection
Research output: Contribution to journal › Journal article › Research › peer-review
Among a subgroup of participants in the Strategies for Management of Antiretroviral Therapy (SMART) Trial that were naïve to antiretroviral therapy (ART) or off ART (6 months or longer) at study entry, risk of AIDS and serious non-AIDS events were increased for participants who deferred ART compared with those randomized to (re)initiate ART immediately. Our objective was to determine whether ART initiation in this group reduced markers of inflammation and coagulation that have been associated with increased mortality risk in SMART. Changes in these biomarkers have been described after stopping ART, but not after starting ART in SMART.
| Original language | English |
|---|---|
| Journal | J A I D S |
| Volume | 56 |
| Issue number | 1 |
| Pages (from-to) | 36-43 |
| Number of pages | 8 |
| ISSN | 1525-4135 |
| DOIs | |
| Publication status | Published - 1 Jan 2011 |
- Adult, Anti-HIV Agents, Biological Markers, Blood Coagulation, C-Reactive Protein, CD4 Lymphocyte Count, Female, Fibrin Fibrinogen Degradation Products, HIV Infections, Humans, Inflammation, Interleukin-6, Male, Middle Aged, Time Factors, Viral Load
Research areas
ID: 35413701