Changes in autonomic tone during delirium in acute stroke patients assessed by pupillometry and skin conductance
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Changes in autonomic tone during delirium in acute stroke patients assessed by pupillometry and skin conductance. / Stokholm, Jannik; Birkmose, Lars Kristian Hebsgaard; Ahmed, Abd Al Bari Omar; Csillag, Claudio; Kjær, Troels Wesenberg; Christensen, Thomas.
In: Journal of the Neurological Sciences, Vol. 428, 117582, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Changes in autonomic tone during delirium in acute stroke patients assessed by pupillometry and skin conductance
AU - Stokholm, Jannik
AU - Birkmose, Lars Kristian Hebsgaard
AU - Ahmed, Abd Al Bari Omar
AU - Csillag, Claudio
AU - Kjær, Troels Wesenberg
AU - Christensen, Thomas
N1 - Publisher Copyright: © 2021 Elsevier B.V.
PY - 2021
Y1 - 2021
N2 - Delirium is a common complication in acute ischemic stroke, possibly caused by alterations in the regulation of the sympathetic autonomic nervous system. We investigated whether such an association could be demonstrated with two easy-to-use measurement techniques: Measurement of palmar skin conductance level (SCL) and pupillometry measuring the dilation velocity in the pupillary light reflex (PLRdil.vel.). The cohort study included 64 patients admitted with acute ischemic stroke. During the study period (median 4.1 days, interquartile range 2.1 days) patients were assessed for delirium once daily as well as with measurements of SCL and PLRdil.vel up to twice daily. SCL and PLRdil.vel. during delirium were lower than without delirium present. For SCL the unadjusted difference was −40.8% (95% CI (−55.1 to −22.0), P value <.001) and for PLRdil.vel the unadjusted difference was −0.22 mm/s (95% CI (−0.42 to −0.01), P value = .041). The results demonstrate changes in sympathetic autonomic nervous system regulation during delirium in acute stroke patients.
AB - Delirium is a common complication in acute ischemic stroke, possibly caused by alterations in the regulation of the sympathetic autonomic nervous system. We investigated whether such an association could be demonstrated with two easy-to-use measurement techniques: Measurement of palmar skin conductance level (SCL) and pupillometry measuring the dilation velocity in the pupillary light reflex (PLRdil.vel.). The cohort study included 64 patients admitted with acute ischemic stroke. During the study period (median 4.1 days, interquartile range 2.1 days) patients were assessed for delirium once daily as well as with measurements of SCL and PLRdil.vel up to twice daily. SCL and PLRdil.vel. during delirium were lower than without delirium present. For SCL the unadjusted difference was −40.8% (95% CI (−55.1 to −22.0), P value <.001) and for PLRdil.vel the unadjusted difference was −0.22 mm/s (95% CI (−0.42 to −0.01), P value = .041). The results demonstrate changes in sympathetic autonomic nervous system regulation during delirium in acute stroke patients.
KW - Autonomic nervous system
KW - Delirium
KW - Stroke
U2 - 10.1016/j.jns.2021.117582
DO - 10.1016/j.jns.2021.117582
M3 - Journal article
C2 - 34284172
AN - SCOPUS:85110333993
VL - 428
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
SN - 0022-510X
M1 - 117582
ER -
ID: 275772044