Cellular bioenergetics in human iPSC-derived glutamatergic neurons in health and disease

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

Cellular bioenergetics in human iPSC-derived glutamatergic neurons in health and disease. / Aldana, Blanca I.; Salcedo, Claudia; Freude, Kristine K.; Waagepetersen, Helle S.

Current Progress in iPSC-derived Cell Types. ed. / Alexander Birbrair. Elsevier, 2021. p. 205-221 (Advances in Stem Cell Biology, Vol. 10).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Aldana, BI, Salcedo, C, Freude, KK & Waagepetersen, HS 2021, Cellular bioenergetics in human iPSC-derived glutamatergic neurons in health and disease. in A Birbrair (ed.), Current Progress in iPSC-derived Cell Types. Elsevier, Advances in Stem Cell Biology, vol. 10, pp. 205-221. https://doi.org/10.1016/B978-0-12-823884-4.00008-0

APA

Aldana, B. I., Salcedo, C., Freude, K. K., & Waagepetersen, H. S. (2021). Cellular bioenergetics in human iPSC-derived glutamatergic neurons in health and disease. In A. Birbrair (Ed.), Current Progress in iPSC-derived Cell Types (pp. 205-221). Elsevier. Advances in Stem Cell Biology Vol. 10 https://doi.org/10.1016/B978-0-12-823884-4.00008-0

Vancouver

Aldana BI, Salcedo C, Freude KK, Waagepetersen HS. Cellular bioenergetics in human iPSC-derived glutamatergic neurons in health and disease. In Birbrair A, editor, Current Progress in iPSC-derived Cell Types. Elsevier. 2021. p. 205-221. (Advances in Stem Cell Biology, Vol. 10). https://doi.org/10.1016/B978-0-12-823884-4.00008-0

Author

Aldana, Blanca I. ; Salcedo, Claudia ; Freude, Kristine K. ; Waagepetersen, Helle S. / Cellular bioenergetics in human iPSC-derived glutamatergic neurons in health and disease. Current Progress in iPSC-derived Cell Types. editor / Alexander Birbrair. Elsevier, 2021. pp. 205-221 (Advances in Stem Cell Biology, Vol. 10).

Bibtex

@inbook{76511b88f2bd4af5afbd856f61f07634,
title = "Cellular bioenergetics in human iPSC-derived glutamatergic neurons in health and disease",
abstract = "Neurodegenerative diseases (NDs) are chronic, progressive disorders that present with severe cognitive decline affecting the aging population. Fundamental investigations have identified key pathological processes including abnormal protein aggregation, neurotransmitter imbalances, and overall bioenergetic dysfunction. Intriguingly, the glutamatergic neurotransmitter system in the cerebral cortex appears to be particularly affected in NDs, and disturbances in its circuits have been associated with memory impairments. To date, no treatment is available to prevent disease progression. Efforts to develop successful therapeutics may benefit from disease-relevant models that enable the study of early pathology stages. Models based on human-induced pluripotent stem cells (hiPSCs) hold great promise as approaches to unravel mechanistic insights in specific neuronal populations affected in NDs. Here we revisit the current approaches differentiating hiPSCs into cortical glutamatergic neurons in order to assess neuronal hypometabolism, one of the most prevalent early phenotype in NDs, followed by an overview of studies evaluating brain energy metabolism in hiPSC-derived (glutamatergic) neurons from ND patients.",
keywords = "Alzheimer{\textquoteright}s disease, Amyotrophic lateral sclerosis, Bioenergetics, Cerebral cortex, Energy metabolism, Frontotemporal dementia, Glutamate, Huntington{\textquoteright}s disease, Metabolomics, Mitochondria, Neurodegeneration, Neurodegenerative diseases, Neurons, Parkinson{\textquoteright}s disease",
author = "Aldana, {Blanca I.} and Claudia Salcedo and Freude, {Kristine K.} and Waagepetersen, {Helle S.}",
note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
doi = "10.1016/B978-0-12-823884-4.00008-0",
language = "English",
series = "Advances in Stem Cell Biology",
publisher = "Elsevier",
pages = "205--221",
editor = "Alexander Birbrair",
booktitle = "Current Progress in iPSC-derived Cell Types",
address = "Netherlands",

}

RIS

TY - CHAP

T1 - Cellular bioenergetics in human iPSC-derived glutamatergic neurons in health and disease

AU - Aldana, Blanca I.

AU - Salcedo, Claudia

AU - Freude, Kristine K.

AU - Waagepetersen, Helle S.

N1 - Publisher Copyright: © 2021 Elsevier Inc.

PY - 2021

Y1 - 2021

N2 - Neurodegenerative diseases (NDs) are chronic, progressive disorders that present with severe cognitive decline affecting the aging population. Fundamental investigations have identified key pathological processes including abnormal protein aggregation, neurotransmitter imbalances, and overall bioenergetic dysfunction. Intriguingly, the glutamatergic neurotransmitter system in the cerebral cortex appears to be particularly affected in NDs, and disturbances in its circuits have been associated with memory impairments. To date, no treatment is available to prevent disease progression. Efforts to develop successful therapeutics may benefit from disease-relevant models that enable the study of early pathology stages. Models based on human-induced pluripotent stem cells (hiPSCs) hold great promise as approaches to unravel mechanistic insights in specific neuronal populations affected in NDs. Here we revisit the current approaches differentiating hiPSCs into cortical glutamatergic neurons in order to assess neuronal hypometabolism, one of the most prevalent early phenotype in NDs, followed by an overview of studies evaluating brain energy metabolism in hiPSC-derived (glutamatergic) neurons from ND patients.

AB - Neurodegenerative diseases (NDs) are chronic, progressive disorders that present with severe cognitive decline affecting the aging population. Fundamental investigations have identified key pathological processes including abnormal protein aggregation, neurotransmitter imbalances, and overall bioenergetic dysfunction. Intriguingly, the glutamatergic neurotransmitter system in the cerebral cortex appears to be particularly affected in NDs, and disturbances in its circuits have been associated with memory impairments. To date, no treatment is available to prevent disease progression. Efforts to develop successful therapeutics may benefit from disease-relevant models that enable the study of early pathology stages. Models based on human-induced pluripotent stem cells (hiPSCs) hold great promise as approaches to unravel mechanistic insights in specific neuronal populations affected in NDs. Here we revisit the current approaches differentiating hiPSCs into cortical glutamatergic neurons in order to assess neuronal hypometabolism, one of the most prevalent early phenotype in NDs, followed by an overview of studies evaluating brain energy metabolism in hiPSC-derived (glutamatergic) neurons from ND patients.

KW - Alzheimer’s disease

KW - Amyotrophic lateral sclerosis

KW - Bioenergetics

KW - Cerebral cortex

KW - Energy metabolism

KW - Frontotemporal dementia

KW - Glutamate

KW - Huntington’s disease

KW - Metabolomics

KW - Mitochondria

KW - Neurodegeneration

KW - Neurodegenerative diseases

KW - Neurons

KW - Parkinson’s disease

U2 - 10.1016/B978-0-12-823884-4.00008-0

DO - 10.1016/B978-0-12-823884-4.00008-0

M3 - Book chapter

AN - SCOPUS:85127690644

T3 - Advances in Stem Cell Biology

SP - 205

EP - 221

BT - Current Progress in iPSC-derived Cell Types

A2 - Birbrair, Alexander

PB - Elsevier

ER -

ID: 306973629