CD25 shedding by human natural occurring CD4+CD25+ regulatory T cells does not inhibit the action of IL-2

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

CD25 shedding by human natural occurring CD4+CD25+ regulatory T cells does not inhibit the action of IL-2. / Pedersen, Anders Elm; Lauritsen, Jens Peter Holst.

In: Scandinavian Journal of Immunology, Vol. 70, No. 1, 2009, p. 40-3.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Pedersen, AE & Lauritsen, JPH 2009, 'CD25 shedding by human natural occurring CD4+CD25+ regulatory T cells does not inhibit the action of IL-2', Scandinavian Journal of Immunology, vol. 70, no. 1, pp. 40-3. https://doi.org/10.1111/j.1365-3083.2009.02268.x

APA

Pedersen, A. E., & Lauritsen, J. P. H. (2009). CD25 shedding by human natural occurring CD4+CD25+ regulatory T cells does not inhibit the action of IL-2. Scandinavian Journal of Immunology, 70(1), 40-3. https://doi.org/10.1111/j.1365-3083.2009.02268.x

Vancouver

Pedersen AE, Lauritsen JPH. CD25 shedding by human natural occurring CD4+CD25+ regulatory T cells does not inhibit the action of IL-2. Scandinavian Journal of Immunology. 2009;70(1):40-3. https://doi.org/10.1111/j.1365-3083.2009.02268.x

Author

Pedersen, Anders Elm ; Lauritsen, Jens Peter Holst. / CD25 shedding by human natural occurring CD4+CD25+ regulatory T cells does not inhibit the action of IL-2. In: Scandinavian Journal of Immunology. 2009 ; Vol. 70, No. 1. pp. 40-3.

Bibtex

@article{070c6400649911de8bc9000ea68e967b,
title = "CD25 shedding by human natural occurring CD4+CD25+ regulatory T cells does not inhibit the action of IL-2",
abstract = "Regulatory T (Treg) cells are important for the maintenance of peripheral tolerance and inhibition of pathogenic T-cell responses. Therefore, they are important for the limitation of chronic inflammation but can also be deleterious by e.g. limiting antitumour immune responses. Natural occurring Tregs are known to inhibit CD4+ T cell in a contact-dependent manner, but at the same time, various suppressive factors are secreted. We, here, demonstrate that human naturally occurring CD4+CD25+ Tregs are able to shed large amounts of soluble CD25 upon activation. Secretion of sCD25 could add to the inhibitory effect of Tregs as such secretion in other settings has been proposed to act as a sink for local IL-2. However, we here demonstrate that supernatant from human Tregs containing high concentration of sCD25 does not inhibit proliferation of CD4+CD25(-) T cells or inhibit the action of IL-2 in an in vitro bioassay.",
author = "Pedersen, {Anders Elm} and Lauritsen, {Jens Peter Holst}",
year = "2009",
doi = "10.1111/j.1365-3083.2009.02268.x",
language = "English",
volume = "70",
pages = "40--3",
journal = "Scandinavian Journal of Immunology, Supplement",
issn = "0301-6323",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - CD25 shedding by human natural occurring CD4+CD25+ regulatory T cells does not inhibit the action of IL-2

AU - Pedersen, Anders Elm

AU - Lauritsen, Jens Peter Holst

PY - 2009

Y1 - 2009

N2 - Regulatory T (Treg) cells are important for the maintenance of peripheral tolerance and inhibition of pathogenic T-cell responses. Therefore, they are important for the limitation of chronic inflammation but can also be deleterious by e.g. limiting antitumour immune responses. Natural occurring Tregs are known to inhibit CD4+ T cell in a contact-dependent manner, but at the same time, various suppressive factors are secreted. We, here, demonstrate that human naturally occurring CD4+CD25+ Tregs are able to shed large amounts of soluble CD25 upon activation. Secretion of sCD25 could add to the inhibitory effect of Tregs as such secretion in other settings has been proposed to act as a sink for local IL-2. However, we here demonstrate that supernatant from human Tregs containing high concentration of sCD25 does not inhibit proliferation of CD4+CD25(-) T cells or inhibit the action of IL-2 in an in vitro bioassay.

AB - Regulatory T (Treg) cells are important for the maintenance of peripheral tolerance and inhibition of pathogenic T-cell responses. Therefore, they are important for the limitation of chronic inflammation but can also be deleterious by e.g. limiting antitumour immune responses. Natural occurring Tregs are known to inhibit CD4+ T cell in a contact-dependent manner, but at the same time, various suppressive factors are secreted. We, here, demonstrate that human naturally occurring CD4+CD25+ Tregs are able to shed large amounts of soluble CD25 upon activation. Secretion of sCD25 could add to the inhibitory effect of Tregs as such secretion in other settings has been proposed to act as a sink for local IL-2. However, we here demonstrate that supernatant from human Tregs containing high concentration of sCD25 does not inhibit proliferation of CD4+CD25(-) T cells or inhibit the action of IL-2 in an in vitro bioassay.

U2 - 10.1111/j.1365-3083.2009.02268.x

DO - 10.1111/j.1365-3083.2009.02268.x

M3 - Journal article

C2 - 19522766

VL - 70

SP - 40

EP - 43

JO - Scandinavian Journal of Immunology, Supplement

JF - Scandinavian Journal of Immunology, Supplement

SN - 0301-6323

IS - 1

ER -

ID: 12868304