Cause-Specific Stillbirth and Neonatal Death According to Prepregnancy Obesity and Early Gestational Weight Gain: A Study in the Danish National Birth Cohort
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Cause-Specific Stillbirth and Neonatal Death According to Prepregnancy Obesity and Early Gestational Weight Gain : A Study in the Danish National Birth Cohort. / Nohr, Ellen Aagaard; Wolff, Sanne; Kirkegaard, Helene; Wu, Chunsen; Andersen, Anne-Marie Nybo; Olsen, Jorn; Bech, Bodil Hammer.
In: Nutrients, Vol. 13, No. 5, 1676, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cause-Specific Stillbirth and Neonatal Death According to Prepregnancy Obesity and Early Gestational Weight Gain
T2 - A Study in the Danish National Birth Cohort
AU - Nohr, Ellen Aagaard
AU - Wolff, Sanne
AU - Kirkegaard, Helene
AU - Wu, Chunsen
AU - Andersen, Anne-Marie Nybo
AU - Olsen, Jorn
AU - Bech, Bodil Hammer
PY - 2021
Y1 - 2021
N2 - Maternal obesity is associated with impaired fetal and neonatal survival, but underlying mechanisms are poorly understood. We examined how prepregnancy BMI and early gestational weight gain (GWG) were associated with cause-specific stillbirth and neonatal death. In 85,822 pregnancies in the Danish National Birth Cohort (1996-2002), we identified causes of death from medical records for 272 late stillbirths and 228 neonatal deaths. Prepregnancy BMI and early GWG derived from an early pregnancy interview and Cox regression were used to estimate associations with stillbirth or neonatal death as a combined outcome and nine specific cause-of-death categories. Compared to women with normal weight, risk of stillbirth or neonatal death was increased by 66% with overweight and 78% with obesity. Especially deaths due to placental dysfunction, umbilical cord complications, intrapartum events, and infections were increased in women with obesity. More stillbirths and neonatal deaths were observed in women with BMI < 25 and low GWG. Additionally, unexplained intrauterine death was increased with low GWG, while more early stillbirths were seen with both low and high GWG. In conclusion, causes of death that relate to vascular and metabolic disturbances were increased in women with obesity. Low early GWG in women of normal weight deserves more clinical attention.
AB - Maternal obesity is associated with impaired fetal and neonatal survival, but underlying mechanisms are poorly understood. We examined how prepregnancy BMI and early gestational weight gain (GWG) were associated with cause-specific stillbirth and neonatal death. In 85,822 pregnancies in the Danish National Birth Cohort (1996-2002), we identified causes of death from medical records for 272 late stillbirths and 228 neonatal deaths. Prepregnancy BMI and early GWG derived from an early pregnancy interview and Cox regression were used to estimate associations with stillbirth or neonatal death as a combined outcome and nine specific cause-of-death categories. Compared to women with normal weight, risk of stillbirth or neonatal death was increased by 66% with overweight and 78% with obesity. Especially deaths due to placental dysfunction, umbilical cord complications, intrapartum events, and infections were increased in women with obesity. More stillbirths and neonatal deaths were observed in women with BMI < 25 and low GWG. Additionally, unexplained intrauterine death was increased with low GWG, while more early stillbirths were seen with both low and high GWG. In conclusion, causes of death that relate to vascular and metabolic disturbances were increased in women with obesity. Low early GWG in women of normal weight deserves more clinical attention.
KW - fetal death
KW - stillbirth
KW - neonatal death
KW - pregnancy
KW - obesity
KW - body mass index
KW - gestational weight gain
KW - gestational weight loss
KW - BODY-MASS INDEX
KW - CLASSIFYING PERINATAL DEATH
KW - HIGH-FAT DIET
KW - MATERNAL OBESITY
KW - INFANT-DEATH
KW - FETAL-DEATH
KW - EARLY-PREGNANCY
KW - POSTTERM BIRTH
KW - RISK
KW - ASSOCIATION
U2 - 10.3390/nu13051676
DO - 10.3390/nu13051676
M3 - Journal article
C2 - 34063336
VL - 13
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 5
M1 - 1676
ER -
ID: 273124879