β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4. / Funa, Nina Sofi Ayumi; Schachter, Karen; Lerdrup, Mads; Ekberg, Jenny; Hess, Katja; Dietrich, Nikolaj; Honore, Christian; Hansen, Klaus; Semb, Tor Henrik.

In: Cell Stem Cell, Vol. 16, No. 6, 2015, p. 639-52.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Funa, NSA, Schachter, K, Lerdrup, M, Ekberg, J, Hess, K, Dietrich, N, Honore, C, Hansen, K & Semb, TH 2015, 'β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4', Cell Stem Cell, vol. 16, no. 6, pp. 639-52. https://doi.org/10.1016/j.stem.2015.03.008

APA

Funa, N. S. A., Schachter, K., Lerdrup, M., Ekberg, J., Hess, K., Dietrich, N., Honore, C., Hansen, K., & Semb, T. H. (2015). β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4. Cell Stem Cell, 16(6), 639-52. https://doi.org/10.1016/j.stem.2015.03.008

Vancouver

Funa NSA, Schachter K, Lerdrup M, Ekberg J, Hess K, Dietrich N et al. β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4. Cell Stem Cell. 2015;16(6):639-52. https://doi.org/10.1016/j.stem.2015.03.008

Author

Funa, Nina Sofi Ayumi ; Schachter, Karen ; Lerdrup, Mads ; Ekberg, Jenny ; Hess, Katja ; Dietrich, Nikolaj ; Honore, Christian ; Hansen, Klaus ; Semb, Tor Henrik. / β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4. In: Cell Stem Cell. 2015 ; Vol. 16, No. 6. pp. 639-52.

Bibtex

@article{6ccd359b6f60434281b06e4b248cf433,
title = "β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4",
abstract = "Canonical Wnt and Nodal signaling are both requiredfor induction of the primitive streak (PS), whichguides organization of the early embryo. The Wnteffector b-catenin is thought to function in theseearly lineage specification decisions via transcriptionalactivation of Nodal signaling. Here, we demonstratea broader role for b-catenin in PS formation byanalyzing its genome-wide binding in a human embryonicstem cell model of PS induction. b-cateninoccupies regulatory regions in numerous PS andneural crest genes, and direct interactions betweenb-catenin and the Nodal effectors SMAD2/SMAD3are required at these regions for PS gene activation.Furthermore, OCT4 binding in proximity to thesesites is likewise required for PS induction, suggestinga collaborative interaction between b-catenin andOCT4. Induction of neural crest genes by b-cateninis repressed by SMAD2/SMAD3, ensuring properlineage specification. This study provides mechanisticinsight into how Wnt signaling controls earlycell lineage decisions.",
author = "Funa, {Nina Sofi Ayumi} and Karen Schachter and Mads Lerdrup and Jenny Ekberg and Katja Hess and Nikolaj Dietrich and Christian Honore and Klaus Hansen and Semb, {Tor Henrik}",
year = "2015",
doi = "10.1016/j.stem.2015.03.008",
language = "English",
volume = "16",
pages = "639--52",
journal = "Cell Stem Cell",
issn = "1934-5909",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4

AU - Funa, Nina Sofi Ayumi

AU - Schachter, Karen

AU - Lerdrup, Mads

AU - Ekberg, Jenny

AU - Hess, Katja

AU - Dietrich, Nikolaj

AU - Honore, Christian

AU - Hansen, Klaus

AU - Semb, Tor Henrik

PY - 2015

Y1 - 2015

N2 - Canonical Wnt and Nodal signaling are both requiredfor induction of the primitive streak (PS), whichguides organization of the early embryo. The Wnteffector b-catenin is thought to function in theseearly lineage specification decisions via transcriptionalactivation of Nodal signaling. Here, we demonstratea broader role for b-catenin in PS formation byanalyzing its genome-wide binding in a human embryonicstem cell model of PS induction. b-cateninoccupies regulatory regions in numerous PS andneural crest genes, and direct interactions betweenb-catenin and the Nodal effectors SMAD2/SMAD3are required at these regions for PS gene activation.Furthermore, OCT4 binding in proximity to thesesites is likewise required for PS induction, suggestinga collaborative interaction between b-catenin andOCT4. Induction of neural crest genes by b-cateninis repressed by SMAD2/SMAD3, ensuring properlineage specification. This study provides mechanisticinsight into how Wnt signaling controls earlycell lineage decisions.

AB - Canonical Wnt and Nodal signaling are both requiredfor induction of the primitive streak (PS), whichguides organization of the early embryo. The Wnteffector b-catenin is thought to function in theseearly lineage specification decisions via transcriptionalactivation of Nodal signaling. Here, we demonstratea broader role for b-catenin in PS formation byanalyzing its genome-wide binding in a human embryonicstem cell model of PS induction. b-cateninoccupies regulatory regions in numerous PS andneural crest genes, and direct interactions betweenb-catenin and the Nodal effectors SMAD2/SMAD3are required at these regions for PS gene activation.Furthermore, OCT4 binding in proximity to thesesites is likewise required for PS induction, suggestinga collaborative interaction between b-catenin andOCT4. Induction of neural crest genes by b-cateninis repressed by SMAD2/SMAD3, ensuring properlineage specification. This study provides mechanisticinsight into how Wnt signaling controls earlycell lineage decisions.

U2 - 10.1016/j.stem.2015.03.008

DO - 10.1016/j.stem.2015.03.008

M3 - Journal article

C2 - 25921273

VL - 16

SP - 639

EP - 652

JO - Cell Stem Cell

JF - Cell Stem Cell

SN - 1934-5909

IS - 6

ER -

ID: 136757405