Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells

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Almstrup, Kristian
J E Nielsen
O Mlynarska
M T Jansen
A Jørgensen
Skakkebæk, Niels Erik
E Rajpert-De Meyts

The majority of testicular germ cell cancers develop through a pre-invasive carcinoma in situ (CIS) stage. The CIS cell is a neoplastic counterpart of foetal germ cells. During their development, foetal germ cells undergo extensive and essential epigenetic modifications, but little is known about epigenetic patterns in CIS cells.

Original language	English
Journal	British Journal of Cancer
Volume	103
Issue number	8
Pages (from-to)	1269-76
Number of pages	8
ISSN	0007-0920
DOIs	https://doi.org/10.1038/sj.bjc.6605880
Publication status	Published - 12 Oct 2010

ID: 34118424