Carboxylesterase 1 gene duplication and mRNA expression in adipose tissue are linked to obesity and metabolic function

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CONTEXT AND AIMS: Carboxylesterase 1 (CES1) appears to play an important role in the control of the metabolism of triglycerides and cholesterol in adipocytes and other cell types including hepatocytes. Therefore, it is relevant to gain insights into the genetic versus non-genetic mechanisms involved in the control of mRNA expression. Here, we investigated mRNA expression level in adipose tissue and its association with measures of adiposity and metabolic function in a population of elderly twins. Furthermore, the heritability of mRNA expression level in adipose tissue and the effect of gene duplication were assessed.
Original languageEnglish
JournalP L o S One
Volume8
Issue number2
Pages (from-to)e56861
Number of pages7
ISSN1932-6203
DOIs
Publication statusPublished - 2013

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