Can we prevent obesity-related metabolic diseases by dietary modulation of the gut microbiota?
Research output: Contribution to journal › Review › Research › peer-review
Obesity increases the risk of type 2 diabetes, cardiovascular diseases, and certain cancers, which are among the leading causes of death worldwide. Obesity and obesity-related metabolic diseases are characterized by specific alterations in the human gut microbiota. Experimental studies with gut microbiota transplantations in mice and in humans indicate that a specific gut microbiota composition can be the cause and not just the consequence of the obese state and metabolic disease, which suggests a potential for gut microbiota modulation in prevention and treatment of obesity-related metabolic diseases. In addition, dietary intervention studies have suggested that modulation of the gut microbiota can improve metabolic risk markers in humans, but a causal role of the gut microbiota in such studies has not yet been established. Here, we review and discuss the role of the gut microbiota in obesity-related metabolic diseases and the potential of dietary modulation of the gut microbiota in metabolic disease prevention and treatment.
Original language | English |
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Journal | Advances in Nutrition |
Volume | 7 |
Issue number | 1 |
Pages (from-to) | 90-101 |
Number of pages | 12 |
ISSN | 2161-8313 |
DOIs | |
Publication status | Published - 2016 |
ID: 154143396