Can strain elastography predict malignancy of soft tissue tumors in a tertiary sarcoma center?

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Can strain elastography predict malignancy of soft tissue tumors in a tertiary sarcoma center? / Cohen, Jonathan; Riishede, Iben; Carlsen, Jonathan Frederik; Lambine, Trine Lise; Dam, Mikkel Seidelin; Petersen, Michael Mørk; Nielsen, Michael Bachmann; Ewertsen, Caroline.

In: Diagnostics, Vol. 10, No. 3, 148, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Cohen, J, Riishede, I, Carlsen, JF, Lambine, TL, Dam, MS, Petersen, MM, Nielsen, MB & Ewertsen, C 2020, 'Can strain elastography predict malignancy of soft tissue tumors in a tertiary sarcoma center?', Diagnostics, vol. 10, no. 3, 148. https://doi.org/10.3390/diagnostics10030148

APA

Cohen, J., Riishede, I., Carlsen, J. F., Lambine, T. L., Dam, M. S., Petersen, M. M., Nielsen, M. B., & Ewertsen, C. (2020). Can strain elastography predict malignancy of soft tissue tumors in a tertiary sarcoma center? Diagnostics, 10(3), [148]. https://doi.org/10.3390/diagnostics10030148

Vancouver

Cohen J, Riishede I, Carlsen JF, Lambine TL, Dam MS, Petersen MM et al. Can strain elastography predict malignancy of soft tissue tumors in a tertiary sarcoma center? Diagnostics. 2020;10(3). 148. https://doi.org/10.3390/diagnostics10030148

Author

Cohen, Jonathan ; Riishede, Iben ; Carlsen, Jonathan Frederik ; Lambine, Trine Lise ; Dam, Mikkel Seidelin ; Petersen, Michael Mørk ; Nielsen, Michael Bachmann ; Ewertsen, Caroline. / Can strain elastography predict malignancy of soft tissue tumors in a tertiary sarcoma center?. In: Diagnostics. 2020 ; Vol. 10, No. 3.

Bibtex

@article{917ec752d2c54e0898bd181961e83310,
title = "Can strain elastography predict malignancy of soft tissue tumors in a tertiary sarcoma center?",
abstract = "This study aims to investigate the ability of ultrasound strain elastography as an adjunct to predict malignancy in soft tissue tumors suspect of sarcoma or metastasis in a tertiary reference center for sarcoma. A total of 137 patients were included prospectively. Patients were referred on the basis of clinical or radiological suspicion of malignant soft tissue tumor. All patients had previously undergone diagnostic imaging (MRI, CT or PET-CT). After recording strain elastography cine loops, ultrasound guided biopsy was performed. Three investigators, who were blinded to final diagnosis, reviewed all elastograms retrospectively. For each elastogram, a qualitative, visual 5-point score was decided in consensus and a strain ratio was calculated. Final pathology obtained from biopsy or tumor resection served as gold standard. Eighty-one tumors were benign, and 56 were malignant. t-tests showed a significant difference in mean visual score between benign and malignant tumors. There was no significant difference in mean strain ratio between the two groups. Strain elastography may be a valuable adjunct to conventional B-mode ultrasound, perhaps primarily in primary care, when considering whether to refer to a sarcoma center or to biopsy, although biopsies cannot reliably be ruled out based on the current data.",
keywords = "Diagnostic ultrasound, Elastography, Sarcoma, Soft tissue tumors, Strain ratio, Tsukuba elasticity score",
author = "Jonathan Cohen and Iben Riishede and Carlsen, {Jonathan Frederik} and Lambine, {Trine Lise} and Dam, {Mikkel Seidelin} and Petersen, {Michael M{\o}rk} and Nielsen, {Michael Bachmann} and Caroline Ewertsen",
year = "2020",
doi = "10.3390/diagnostics10030148",
language = "English",
volume = "10",
journal = "Diagnostics",
issn = "2075-4418",
publisher = "MDPI AG",
number = "3",

}

RIS

TY - JOUR

T1 - Can strain elastography predict malignancy of soft tissue tumors in a tertiary sarcoma center?

AU - Cohen, Jonathan

AU - Riishede, Iben

AU - Carlsen, Jonathan Frederik

AU - Lambine, Trine Lise

AU - Dam, Mikkel Seidelin

AU - Petersen, Michael Mørk

AU - Nielsen, Michael Bachmann

AU - Ewertsen, Caroline

PY - 2020

Y1 - 2020

N2 - This study aims to investigate the ability of ultrasound strain elastography as an adjunct to predict malignancy in soft tissue tumors suspect of sarcoma or metastasis in a tertiary reference center for sarcoma. A total of 137 patients were included prospectively. Patients were referred on the basis of clinical or radiological suspicion of malignant soft tissue tumor. All patients had previously undergone diagnostic imaging (MRI, CT or PET-CT). After recording strain elastography cine loops, ultrasound guided biopsy was performed. Three investigators, who were blinded to final diagnosis, reviewed all elastograms retrospectively. For each elastogram, a qualitative, visual 5-point score was decided in consensus and a strain ratio was calculated. Final pathology obtained from biopsy or tumor resection served as gold standard. Eighty-one tumors were benign, and 56 were malignant. t-tests showed a significant difference in mean visual score between benign and malignant tumors. There was no significant difference in mean strain ratio between the two groups. Strain elastography may be a valuable adjunct to conventional B-mode ultrasound, perhaps primarily in primary care, when considering whether to refer to a sarcoma center or to biopsy, although biopsies cannot reliably be ruled out based on the current data.

AB - This study aims to investigate the ability of ultrasound strain elastography as an adjunct to predict malignancy in soft tissue tumors suspect of sarcoma or metastasis in a tertiary reference center for sarcoma. A total of 137 patients were included prospectively. Patients were referred on the basis of clinical or radiological suspicion of malignant soft tissue tumor. All patients had previously undergone diagnostic imaging (MRI, CT or PET-CT). After recording strain elastography cine loops, ultrasound guided biopsy was performed. Three investigators, who were blinded to final diagnosis, reviewed all elastograms retrospectively. For each elastogram, a qualitative, visual 5-point score was decided in consensus and a strain ratio was calculated. Final pathology obtained from biopsy or tumor resection served as gold standard. Eighty-one tumors were benign, and 56 were malignant. t-tests showed a significant difference in mean visual score between benign and malignant tumors. There was no significant difference in mean strain ratio between the two groups. Strain elastography may be a valuable adjunct to conventional B-mode ultrasound, perhaps primarily in primary care, when considering whether to refer to a sarcoma center or to biopsy, although biopsies cannot reliably be ruled out based on the current data.

KW - Diagnostic ultrasound

KW - Elastography

KW - Sarcoma

KW - Soft tissue tumors

KW - Strain ratio

KW - Tsukuba elasticity score

U2 - 10.3390/diagnostics10030148

DO - 10.3390/diagnostics10030148

M3 - Journal article

C2 - 32156078

AN - SCOPUS:85081292299

VL - 10

JO - Diagnostics

JF - Diagnostics

SN - 2075-4418

IS - 3

M1 - 148

ER -

ID: 256216683