Bromadiolone resistance does not respond to absence of anticoagulants in experimental populations of Norway rats.
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Bromadiolone resistance does not respond to absence of anticoagulants in experimental populations of Norway rats. / Heiberg, A.C.; Leirs, H.; Siegismund, Hans Redlef.
Rats, Mice and People: Rodent Biology and Management. ed. / G.R. Singleton; L.A. Hinds; C.J. Krebs; D.M. Spratt. Vol. 96 Canberra, 2003. p. 461-464.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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TY - CHAP
T1 - Bromadiolone resistance does not respond to absence of anticoagulants in experimental populations of Norway rats.
AU - Heiberg, A.C.
AU - Leirs, H.
AU - Siegismund, Hans Redlef
PY - 2003
Y1 - 2003
N2 - Resistance to anticoagulant rodenticides in Norway rats (Rattus norvegicus) is documented to be associatedwith pleiotropic effects, notably with an increased dietary vitamin K requirement. The aim of this study was to quantifythese effects in small populations of Norway rat in Denmark and to see how bromadiolone-resistant phenotypes aremanifested when bromadiolone selection is absent. Experimental populations were established under semi-naturalconditions with wild rats trapped at two Danish farms. The individuals caught on each of the two farms were dividedinto two experimental groups. One group was regularly exposed to bromadiolone whereas the other group wasuntreated. The level of bromadiolone resistance in the experimental populations was followed for two years. Theresults presented here are those results obtained in the absence of bromadiolone selection.The pleiotropic selection against resistance in the two non-treatment populations was found to be insignificant.Thus, absence of anticoagulant, under the environmental conditions provided, did not lead to a selection favouringanticoagulant-sensitive rats. However, we found some evidence of selection against presumed homozygous resistantrats under non-anticoagulant conditions. Haemorrhagic symptoms are not only observed in sensitive rats exposed toanticoagulants, but are also a symptom for severe vitamin K deficiency in resistant rats. This suggests that bromadioloneresistance leads to loss of fitness, albeit that the cost is not strong enough to reduce the phenotypic resistancelevel or minimise the effect of random genetic drift.
AB - Resistance to anticoagulant rodenticides in Norway rats (Rattus norvegicus) is documented to be associatedwith pleiotropic effects, notably with an increased dietary vitamin K requirement. The aim of this study was to quantifythese effects in small populations of Norway rat in Denmark and to see how bromadiolone-resistant phenotypes aremanifested when bromadiolone selection is absent. Experimental populations were established under semi-naturalconditions with wild rats trapped at two Danish farms. The individuals caught on each of the two farms were dividedinto two experimental groups. One group was regularly exposed to bromadiolone whereas the other group wasuntreated. The level of bromadiolone resistance in the experimental populations was followed for two years. Theresults presented here are those results obtained in the absence of bromadiolone selection.The pleiotropic selection against resistance in the two non-treatment populations was found to be insignificant.Thus, absence of anticoagulant, under the environmental conditions provided, did not lead to a selection favouringanticoagulant-sensitive rats. However, we found some evidence of selection against presumed homozygous resistantrats under non-anticoagulant conditions. Haemorrhagic symptoms are not only observed in sensitive rats exposed toanticoagulants, but are also a symptom for severe vitamin K deficiency in resistant rats. This suggests that bromadioloneresistance leads to loss of fitness, albeit that the cost is not strong enough to reduce the phenotypic resistancelevel or minimise the effect of random genetic drift.
M3 - Book chapter
VL - 96
SP - 461
EP - 464
BT - Rats, Mice and People: Rodent Biology and Management
A2 - Singleton, G.R.
A2 - Hinds, L.A.
A2 - Krebs, C.J.
A2 - Spratt, D.M.
CY - Canberra
ER -
ID: 9226437