Brain serotonin 4 receptor binding is inversely associated with verbal memory recall
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Brain serotonin 4 receptor binding is inversely associated with verbal memory recall. / Stenbæk, Dea S; Fisher, Patrick M; Ozenne, Brice; Andersen, Emil; Hjordt, Liv V; McMahon, Brenda; Hasselbalch, Steen G; Frokjaer, Vibe G; Knudsen, Gitte M.
In: Brain and Behavior, Vol. 7, No. 4, e00674, 04.2017.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Brain serotonin 4 receptor binding is inversely associated with verbal memory recall
AU - Stenbæk, Dea S
AU - Fisher, Patrick M
AU - Ozenne, Brice
AU - Andersen, Emil
AU - Hjordt, Liv V
AU - McMahon, Brenda
AU - Hasselbalch, Steen G
AU - Frokjaer, Vibe G
AU - Knudsen, Gitte M
PY - 2017/4
Y1 - 2017/4
N2 - BACKGROUND: We have previously identified an inverse relationship between cerebral serotonin 4 receptor (5-HT 4R) binding and nonaffective episodic memory in healthy individuals. Here, we investigate in a novel sample if the association is related to affective components of memory, by examining the association between cerebral 5-HT 4R binding and affective verbal memory recall.METHODS: Twenty-four healthy volunteers were scanned with the 5-HT 4R radioligand [11C]SB207145 and positron emission tomography, and were tested with the Verbal Affective Memory Test-24. The association between 5-HT 4R binding and affective verbal memory was evaluated using a linear latent variable structural equation model.RESULTS: We observed a significant inverse association across all regions between 5-HT 4R binding and affective verbal memory performances for positive (p = 5.5 × 10-4) and neutral (p = .004) word recall, and an inverse but nonsignificant association for negative (p = .07) word recall. Differences in the associations with 5-HT 4R binding between word categories (i.e., positive, negative, and neutral) did not reach statistical significance.CONCLUSION: Our findings replicate our previous observation of a negative association between 5-HT 4R binding and memory performance in an independent cohort and provide novel evidence linking 5-HT 4R binding, as a biomarker for synaptic 5-HT levels, to the mnestic processing of positive and neutral word stimuli in healthy humans.
AB - BACKGROUND: We have previously identified an inverse relationship between cerebral serotonin 4 receptor (5-HT 4R) binding and nonaffective episodic memory in healthy individuals. Here, we investigate in a novel sample if the association is related to affective components of memory, by examining the association between cerebral 5-HT 4R binding and affective verbal memory recall.METHODS: Twenty-four healthy volunteers were scanned with the 5-HT 4R radioligand [11C]SB207145 and positron emission tomography, and were tested with the Verbal Affective Memory Test-24. The association between 5-HT 4R binding and affective verbal memory was evaluated using a linear latent variable structural equation model.RESULTS: We observed a significant inverse association across all regions between 5-HT 4R binding and affective verbal memory performances for positive (p = 5.5 × 10-4) and neutral (p = .004) word recall, and an inverse but nonsignificant association for negative (p = .07) word recall. Differences in the associations with 5-HT 4R binding between word categories (i.e., positive, negative, and neutral) did not reach statistical significance.CONCLUSION: Our findings replicate our previous observation of a negative association between 5-HT 4R binding and memory performance in an independent cohort and provide novel evidence linking 5-HT 4R binding, as a biomarker for synaptic 5-HT levels, to the mnestic processing of positive and neutral word stimuli in healthy humans.
KW - Adult
KW - Brain/diagnostic imaging
KW - Emotions/physiology
KW - Female
KW - Humans
KW - Male
KW - Mental Recall/physiology
KW - Middle Aged
KW - Neuropsychological Tests
KW - Piperidines
KW - Positron-Emission Tomography
KW - Radiopharmaceuticals
KW - Receptors, Serotonin, 5-HT4/metabolism
KW - Speech Perception/physiology
KW - Young Adult
U2 - 10.1002/brb3.674
DO - 10.1002/brb3.674
M3 - Journal article
C2 - 28413715
VL - 7
JO - Brain and Behavior
JF - Brain and Behavior
SN - 2157-9032
IS - 4
M1 - e00674
ER -
ID: 195160312