Brain Motor Network Changes in Parkinson's Disease: Evidence from Meta-Analytic Modeling
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Brain Motor Network Changes in Parkinson's Disease : Evidence from Meta-Analytic Modeling. / Herz, Damian M.; Meder, David; Camilleri, Julia A.; Eickhoff, Simon B.; Siebner, Hartwig R.
In: Movement Disorders, Vol. 36, No. 5, 2021, p. 1180-1190.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Brain Motor Network Changes in Parkinson's Disease
T2 - Evidence from Meta-Analytic Modeling
AU - Herz, Damian M.
AU - Meder, David
AU - Camilleri, Julia A.
AU - Eickhoff, Simon B.
AU - Siebner, Hartwig R.
PY - 2021
Y1 - 2021
N2 - Background: Motor-related brain activity in Parkinson's disease has been investigated in a multitude of functional neuroimaging studies, which often yielded apparently conflicting results. Our previous meta-analysis did not resolve inconsistencies regarding cortical activation differences in Parkinson's disease, which might be related to the limited number of studies that could be included. Therefore, we conducted a revised meta-analysis including a larger number of studies. The objectives of this study were to elucidate brain areas that consistently show abnormal motor-related activation in Parkinson's disease and to reveal their functional connectivity profiles using meta-analytic approaches. Methods: We applied a quantitative meta-analysis of functional neuroimaging studies testing limb movements in Parkinson's disease comprising data from 39 studies, of which 15 studies (285 of 571 individual patients) were published after the previous meta-analysis. We also conducted meta-analytic connectivity modeling to elucidate the connectivity profiles of areas showing abnormal activation. Results: We found consistent motor-related underactivation of bilateral posterior putamen and cerebellum in Parkinson's disease. Primary motor cortex and the supplementary motor area also showed deficient activation, whereas cortical regions localized directly anterior to these areas expressed overactivation. Connectivity modeling revealed that areas showing decreased activation shared a common pathway through the posterior putamen, whereas areas showing increased activation were connected to the anterior putamen. Conclusions: Despite conflicting results in individual neuroimaging studies, this revised meta-analytic approach identified consistent patterns of abnormal motor-related activation in Parkinson's disease. The distinct patterns of decreased and increased activity might be determined by their connectivity with different subregions of the putamen.
AB - Background: Motor-related brain activity in Parkinson's disease has been investigated in a multitude of functional neuroimaging studies, which often yielded apparently conflicting results. Our previous meta-analysis did not resolve inconsistencies regarding cortical activation differences in Parkinson's disease, which might be related to the limited number of studies that could be included. Therefore, we conducted a revised meta-analysis including a larger number of studies. The objectives of this study were to elucidate brain areas that consistently show abnormal motor-related activation in Parkinson's disease and to reveal their functional connectivity profiles using meta-analytic approaches. Methods: We applied a quantitative meta-analysis of functional neuroimaging studies testing limb movements in Parkinson's disease comprising data from 39 studies, of which 15 studies (285 of 571 individual patients) were published after the previous meta-analysis. We also conducted meta-analytic connectivity modeling to elucidate the connectivity profiles of areas showing abnormal activation. Results: We found consistent motor-related underactivation of bilateral posterior putamen and cerebellum in Parkinson's disease. Primary motor cortex and the supplementary motor area also showed deficient activation, whereas cortical regions localized directly anterior to these areas expressed overactivation. Connectivity modeling revealed that areas showing decreased activation shared a common pathway through the posterior putamen, whereas areas showing increased activation were connected to the anterior putamen. Conclusions: Despite conflicting results in individual neuroimaging studies, this revised meta-analytic approach identified consistent patterns of abnormal motor-related activation in Parkinson's disease. The distinct patterns of decreased and increased activity might be determined by their connectivity with different subregions of the putamen.
KW - functional neuroimaging
KW - meta-analysis
KW - motor
KW - Parkinson's disease
U2 - 10.1002/mds.28468
DO - 10.1002/mds.28468
M3 - Journal article
C2 - 33427336
AN - SCOPUS:85099080749
VL - 36
SP - 1180
EP - 1190
JO - Movement Disorders
JF - Movement Disorders
SN - 0885-3185
IS - 5
ER -
ID: 255354943