Blood-brain barrier permeability of L-dopa in man
Research output: Contribution to journal › Journal article › Research › peer-review
The permeability of L-dopa across the blood-brain barrier was studied in twelve patients by means of the indicator dilution method. The extraction of [1-14C]L-dopa and [3-14C]L-dopa was 11.7% and 10.4%, respectively. After pretreatment with carbidopa the extraction was unchanged (13.5% and 11.6%). The permeability coefficient (P) was calculated to 0.9 x 10(-5) cm s-1.
| Original language | English |
|---|---|
| Journal | European Journal of Clinical Investigation |
| Volume | 11 |
| Issue number | 3 |
| Pages (from-to) | 231-4 |
| Number of pages | 4 |
| ISSN | 0014-2972 |
| DOIs | |
| Publication status | Published - Jun 1981 |
- Adult, Aged, Blood-Brain Barrier, Capillary Permeability, Carbidopa/pharmacology, Carbon Radioisotopes, Cerebrovascular Circulation, Female, Humans, Levodopa/metabolism, Male, Middle Aged, Radioisotope Dilution Technique
Research areas
ID: 279595766