Blood-brain barrier permeability of L-dopa in man

Research output: Contribution to journal › Journal article › Research › peer-review

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Blood-brain barrier permeability of L-dopa in man. / Friis, M L; Paulson, O B; Hertz, M M; Bolwig, T G.

In: European Journal of Clinical Investigation, Vol. 11, No. 3, 06.1981, p. 231-4.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Friis, ML, Paulson, OB, Hertz, MM & Bolwig, TG 1981, 'Blood-brain barrier permeability of L-dopa in man', European Journal of Clinical Investigation, vol. 11, no. 3, pp. 231-4. https://doi.org/10.1111/j.1365-2362.1981.tb01845.x

APA

Friis, M. L., Paulson, O. B., Hertz, M. M., & Bolwig, T. G. (1981). Blood-brain barrier permeability of L-dopa in man. European Journal of Clinical Investigation, 11(3), 231-4. https://doi.org/10.1111/j.1365-2362.1981.tb01845.x

Vancouver

Friis ML, Paulson OB, Hertz MM, Bolwig TG. Blood-brain barrier permeability of L-dopa in man. European Journal of Clinical Investigation. 1981 Jun;11(3):231-4. https://doi.org/10.1111/j.1365-2362.1981.tb01845.x

Author

Friis, M L ; Paulson, O B ; Hertz, M M ; Bolwig, T G. / Blood-brain barrier permeability of L-dopa in man. In: European Journal of Clinical Investigation. 1981 ; Vol. 11, No. 3. pp. 231-4.

Bibtex

@article{8ce076ba2a67423fa7da90e209751620,
title = "Blood-brain barrier permeability of L-dopa in man",
abstract = "The permeability of L-dopa across the blood-brain barrier was studied in twelve patients by means of the indicator dilution method. The extraction of [1-14C]L-dopa and [3-14C]L-dopa was 11.7% and 10.4%, respectively. After pretreatment with carbidopa the extraction was unchanged (13.5% and 11.6%). The permeability coefficient (P) was calculated to 0.9 x 10(-5) cm s-1.",
keywords = "Adult, Aged, Blood-Brain Barrier, Capillary Permeability, Carbidopa/pharmacology, Carbon Radioisotopes, Cerebrovascular Circulation, Female, Humans, Levodopa/metabolism, Male, Middle Aged, Radioisotope Dilution Technique",
author = "Friis, {M L} and Paulson, {O B} and Hertz, {M M} and Bolwig, {T G}",
year = "1981",
month = jun,
doi = "10.1111/j.1365-2362.1981.tb01845.x",
language = "English",
volume = "11",
pages = "231--4",
journal = "European Journal of Clinical Investigation, Supplement",
issn = "0960-135X",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Blood-brain barrier permeability of L-dopa in man

AU - Friis, M L

AU - Paulson, O B

AU - Hertz, M M

AU - Bolwig, T G

PY - 1981/6

Y1 - 1981/6

N2 - The permeability of L-dopa across the blood-brain barrier was studied in twelve patients by means of the indicator dilution method. The extraction of [1-14C]L-dopa and [3-14C]L-dopa was 11.7% and 10.4%, respectively. After pretreatment with carbidopa the extraction was unchanged (13.5% and 11.6%). The permeability coefficient (P) was calculated to 0.9 x 10(-5) cm s-1.

AB - The permeability of L-dopa across the blood-brain barrier was studied in twelve patients by means of the indicator dilution method. The extraction of [1-14C]L-dopa and [3-14C]L-dopa was 11.7% and 10.4%, respectively. After pretreatment with carbidopa the extraction was unchanged (13.5% and 11.6%). The permeability coefficient (P) was calculated to 0.9 x 10(-5) cm s-1.

KW - Adult

KW - Aged

KW - Blood-Brain Barrier

KW - Capillary Permeability

KW - Carbidopa/pharmacology

KW - Carbon Radioisotopes

KW - Cerebrovascular Circulation

KW - Female

KW - Humans

KW - Levodopa/metabolism

KW - Male

KW - Middle Aged

KW - Radioisotope Dilution Technique

U2 - 10.1111/j.1365-2362.1981.tb01845.x

DO - 10.1111/j.1365-2362.1981.tb01845.x

M3 - Journal article

C2 - 6791943

VL - 11

SP - 231

EP - 234

JO - European Journal of Clinical Investigation, Supplement

JF - European Journal of Clinical Investigation, Supplement

SN - 0960-135X

IS - 3

ER -

ID: 279595766