Binge drinking during pregnancy and risk of seizures in childhood: a study based on the Danish National Birth Cohort
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Binge drinking during pregnancy and risk of seizures in childhood: a study based on the Danish National Birth Cohort. / Sun, Yuelian; Strandberg-Larsen, Katrine; Vestergaard, Mogens; Christensen, Jakob; Nybo Andersen, Anne-Marie; Grønbaek, Morten; Olsen, Jørn.
In: American Journal of Epidemiology, Vol. 169, No. 3, 02.2009, p. 313-22.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Binge drinking during pregnancy and risk of seizures in childhood: a study based on the Danish National Birth Cohort
AU - Sun, Yuelian
AU - Strandberg-Larsen, Katrine
AU - Vestergaard, Mogens
AU - Christensen, Jakob
AU - Nybo Andersen, Anne-Marie
AU - Grønbaek, Morten
AU - Olsen, Jørn
PY - 2009/2
Y1 - 2009/2
N2 - Seizures are often found in children with fetal alcohol syndrome, but it is not known whether binge drinking during pregnancy by nonalcoholic women is associated with an increased risk of seizure disorders in children. The authors conducted a population-based cohort study of 80,526 liveborn singletons in the Danish National Birth Cohort (1996-2002). Information on maternal binge drinking (intake of > or = 5 drinks on a single occasion) was collected in 2 computer-assisted telephone interviews during pregnancy. Children were followed for up to 8 years. Information on neonatal seizures, epilepsy, and febrile seizures was retrieved from the Danish National Hospital Register. Results showed that exposure to binge drinking episodes during pregnancy was not associated with an increased risk of seizure disorders in children, except for those exposed at 11-16 gestational weeks. These children had a 3.15-fold increased risk of neonatal seizures (95% confidence interval: 1.37, 7.25) and a 1.81-fold increased risk of epilepsy (95% confidence interval: 1.13, 2.90). These findings suggest that maternal binge drinking during a specific time period of pregnancy may be associated with an increased risk of specific seizure disorders in the offspring. The results are exploratory, however, and need to be replicated.
AB - Seizures are often found in children with fetal alcohol syndrome, but it is not known whether binge drinking during pregnancy by nonalcoholic women is associated with an increased risk of seizure disorders in children. The authors conducted a population-based cohort study of 80,526 liveborn singletons in the Danish National Birth Cohort (1996-2002). Information on maternal binge drinking (intake of > or = 5 drinks on a single occasion) was collected in 2 computer-assisted telephone interviews during pregnancy. Children were followed for up to 8 years. Information on neonatal seizures, epilepsy, and febrile seizures was retrieved from the Danish National Hospital Register. Results showed that exposure to binge drinking episodes during pregnancy was not associated with an increased risk of seizure disorders in children, except for those exposed at 11-16 gestational weeks. These children had a 3.15-fold increased risk of neonatal seizures (95% confidence interval: 1.37, 7.25) and a 1.81-fold increased risk of epilepsy (95% confidence interval: 1.13, 2.90). These findings suggest that maternal binge drinking during a specific time period of pregnancy may be associated with an increased risk of specific seizure disorders in the offspring. The results are exploratory, however, and need to be replicated.
KW - Adolescent
KW - Adult
KW - Alcohol Drinking
KW - Cohort Studies
KW - Denmark
KW - Epilepsy
KW - Female
KW - Fetal Alcohol Syndrome
KW - Follow-Up Studies
KW - Gestational Age
KW - Humans
KW - Infant, Newborn
KW - Male
KW - Maternal Exposure
KW - Parity
KW - Pregnancy
KW - Prenatal Exposure Delayed Effects
KW - Seizures
KW - Seizures, Febrile
U2 - 10.1093/aje/kwn334
DO - 10.1093/aje/kwn334
M3 - Journal article
C2 - 19064645
VL - 169
SP - 313
EP - 322
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 3
ER -
ID: 32633571