Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes
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Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes. / Nielsen, Dennis Sandris; Krych, Lukasz; Buschard, Karsten; Hansen, Camilla Hartmann Friis; Hansen, Axel Jacob Kornerup.
In: FEBS Letters, Vol. 588, No. 22, 2014, p. 4234-4243.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes
AU - Nielsen, Dennis Sandris
AU - Krych, Lukasz
AU - Buschard, Karsten
AU - Hansen, Camilla Hartmann Friis
AU - Hansen, Axel Jacob Kornerup
N1 - Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
PY - 2014
Y1 - 2014
N2 - Type 1 diabetes (T1D) is an autoimmune disease ultimately leading to destruction of insulin secreting β-cells in the pancreas. Genetic susceptibility plays an important role in T1D etiology, but even mono-zygotic twins only have a concordance rate of around 50%, underlining that other factors than purely genetic are involved in disease development. Here we review the influence of dietary and environmental factors on T1D development in humans as well as animal models. Even though data are still inconclusive, there are strong indications that gut microbiota dysbiosis plays an important role in T1D development and evidence from animal models suggests that gut microbiota manipulation might prove valuable in future prevention of T1D in genetically susceptible individuals.
AB - Type 1 diabetes (T1D) is an autoimmune disease ultimately leading to destruction of insulin secreting β-cells in the pancreas. Genetic susceptibility plays an important role in T1D etiology, but even mono-zygotic twins only have a concordance rate of around 50%, underlining that other factors than purely genetic are involved in disease development. Here we review the influence of dietary and environmental factors on T1D development in humans as well as animal models. Even though data are still inconclusive, there are strong indications that gut microbiota dysbiosis plays an important role in T1D development and evidence from animal models suggests that gut microbiota manipulation might prove valuable in future prevention of T1D in genetically susceptible individuals.
U2 - 10.1016/j.febslet.2014.04.010
DO - 10.1016/j.febslet.2014.04.010
M3 - Journal article
C2 - 24746688
VL - 588
SP - 4234
EP - 4243
JO - F E B S Letters
JF - F E B S Letters
SN - 0014-5793
IS - 22
ER -
ID: 125786466