Behavioural and neurodevelopmental impairment at school age following necrotising enterocolitis in the newborn period
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- journal.pone.0215220
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AIM: The aim of this study was to evaluate long-term behavioural and neurodevelopmental complications of neonatal necrotizing enterocolitis at school age.
METHOD: This was a historic cohort study comparing all surviving children born in Denmark between 1st of January 2002 and 31st of December 2011 with a diagnosis of necrotizing enterocolitis to a group of children without necrotizing enterocolitis, but same gestational age, birth weight and year of birth. Outcomes were investigated through a parental questionnaire. The primary outcome was the Strength and Difficulties Questionnaire score and secondary outcomes were cerebral palsy and impaired head growth.
RESULTS: Response rates were 50% (163 of 328) and 36% (237 of 652) among children with and without necrotizing enterocolitis, respectively. There was a higher rate of abnormal Strength and Difficulties score (23.9 versus 17.8%), moderate/severe cerebral palsy (3.1 versus 0.9%) and small head circumference for age (11.7 versus 7.2%) among children with necrotizing enterocolitis. However, these differences were all statistically insignificant and did not change significantly by adjustment for potential confounders.
CONCLUSION: To our knowledge, this study includes the largest cohort of necrotizing enterocolitis children evaluated for possible long-term complications at school age. The increased risks of behavioural- and neurodevelopmental impairments were statistically insignificant, moderate in magnitude and may be of little clinical importance for management in the neonatal period or when planning follow-up.
Original language | English |
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Article number | e0215220 |
Journal | PLoS ONE |
Volume | 14 |
Issue number | 4 |
Number of pages | 11 |
ISSN | 1932-6203 |
DOIs | |
Publication status | Published - 2019 |
- Adolescent, Age Factors, Cerebral Palsy/epidemiology, Child, Child Behavior Disorders/epidemiology, Child, Preschool, Cohort Studies, Denmark/epidemiology, Developmental Disabilities/epidemiology, Enterocolitis, Necrotizing/complications, Female, Follow-Up Studies, Head/pathology, Humans, Infant, Newborn, Male, Neurodevelopmental Disorders/epidemiology, Risk Factors, Surveys and Questionnaires
Research areas
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