Autonomic nervous system activity in primary Raynaud's phenomenon: Heart rate variability, plasma catecholamines and [123I]MIBG heart scintigraphy

Research output: Contribution to journalJournal articleResearchpeer-review


  • Fulltext

    Final published version, 900 KB, PDF document

Background and Aim: Primary Raynaud's phenomenon (pRP) is characterized by an exaggerated response to cold, resulting in the whitening typically of the fingers and toes. The patients are generally perceived as healthy individuals with a benign condition. However, the condition has been associated with increased cardiovascular mortality and changes in autonomic nervous system activity. This study aimed to investigate whether pRP is associated with pervasive changes in autonomic nervous activity. The hypothesis was that patients with pRP have increased sympathetic nervous activity. Methods: The autonomic nervous activity of 22 patients with pRP was investigated by means of heart rate variability (HRV) and the plasma catecholamine response to head-up tilt and compared with 22 age- and gender-matched controls. In addition, the patients were examined with a [123I]metaiodobenzylguanidine heart scintigraphy and compared with an external control group. Results: The plasma norepinephrine response to head-up tilt was significantly lower in the patient group than in the control group. Similarly, the heart scintigraphy revealed a lower heart-to-mediastinum ratio in the patient group than in the control group. HRV analysis did not reveal significant differences between the groups. Conclusion: The findings of the study showed that the autonomic nervous activity of patients with pRP was altered compared with the activity of healthy individuals. This was observed both during rest and after positional stress, but the findings did not uniformly concur with our initial hypothesis.

Original languageEnglish
JournalClinical Physiology and Functional Imaging
Issue number2
Pages (from-to)104-113
Number of pages10
Publication statusPublished - 2022

Bibliographical note

Publisher Copyright:
© 2021 The Authors. Clinical Physiology and Functional Imaging published by John Wiley & Sons Ltd on behalf of Scandinavian Society of Clinical Physiology and Nuclear Medicine.

    Research areas

  • neurophysiology, parasympathetic nervous system, plasma epinephrine, plasma norepinephrine, sympathetic nervous system, [I] metaiodobenzylguanidine

ID: 314073709