Authentication and assessment of contamination in ancient DNA

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review


Contamination from both present-day humans and postmortem microbial sources is a common challenge in ancient DNA studies. Here we present a suite of tools to assist in the assessment of contamination in ancient DNA data sets. These tools perform standard tests of authenticity of ancient DNA data including detecting the presence of postmortem damage signatures in sequence alignments and quantifying the amount of present-day human contamination.

Original languageEnglish
Title of host publicationAncient DNA : Methods and Protocols
EditorsBeth Shapiro, Axel Barlow, Peter D. Heintzman, Michael Hofreiter, Johanna L. A. Paijmans, André E. R. Soares
Number of pages32
PublisherHumana Press
Publication date2019
Edition2. ed.
ISBN (Print) 978-1-4939-9175-4
ISBN (Electronic)978-1-4939-9176-1
Publication statusPublished - 2019
SeriesMethods in Molecular Biology

    Research areas

  • Ancient DNA, Contamination, DICE, mapDamage2.0, Postmortem damage, Schmutzi

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