Atrial fibrillation and cardiac fibrosis: A review on the potential of extracellular matrix proteins as biomarkers
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Atrial fibrillation and cardiac fibrosis : A review on the potential of extracellular matrix proteins as biomarkers. / Reese-Petersen, Alexander L.; Olesen, Morten S.; Karsdal, Morten A.; Svendsen, Jesper H.; Genovese, Federica.
In: Matrix Biology, Vol. 91-92, No. SI, 2020, p. 188-203.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Atrial fibrillation and cardiac fibrosis
T2 - A review on the potential of extracellular matrix proteins as biomarkers
AU - Reese-Petersen, Alexander L.
AU - Olesen, Morten S.
AU - Karsdal, Morten A.
AU - Svendsen, Jesper H.
AU - Genovese, Federica
PY - 2020
Y1 - 2020
N2 - The involvement of fibrosis as an underlying pathology in heart diseases is becoming increasingly clear. In recent years, fibrosis has been granted a causative role in heart diseases and is now emerging as a major contributor to Atrial Fibrillation (AF) pathogenesis. AF is the most common arrhythmia encountered in the clinic, but the substrate for AF is still being debated. Consensus in the field is a combination of cardiac tissue remodeling, inflammation and genetic predisposition. The extracellular matrix (ECM) is subject of growing investigation, since measuring circulatory biomarkers of ECM formation and degradation provides both diag-nostic and prognostic information. However, fibrosis is not just fibrosis. Each specific collagen biomarker holds information on regulatory mechanisms, as well as information about which section of the ECM is being remodeled, providing a detailed description of cardiac tissue homeostasis. This review entails an overview of the implication of fibrosis in AF, the different collagens and their significance, and the potential of using bio-markers of ECM remodeling as tools for understanding AF pathogenesis and identifying patients at risk for further disease progression. (C) 2020 Elsevier B.V. All rights reserved.
AB - The involvement of fibrosis as an underlying pathology in heart diseases is becoming increasingly clear. In recent years, fibrosis has been granted a causative role in heart diseases and is now emerging as a major contributor to Atrial Fibrillation (AF) pathogenesis. AF is the most common arrhythmia encountered in the clinic, but the substrate for AF is still being debated. Consensus in the field is a combination of cardiac tissue remodeling, inflammation and genetic predisposition. The extracellular matrix (ECM) is subject of growing investigation, since measuring circulatory biomarkers of ECM formation and degradation provides both diag-nostic and prognostic information. However, fibrosis is not just fibrosis. Each specific collagen biomarker holds information on regulatory mechanisms, as well as information about which section of the ECM is being remodeled, providing a detailed description of cardiac tissue homeostasis. This review entails an overview of the implication of fibrosis in AF, the different collagens and their significance, and the potential of using bio-markers of ECM remodeling as tools for understanding AF pathogenesis and identifying patients at risk for further disease progression. (C) 2020 Elsevier B.V. All rights reserved.
KW - C-REACTIVE PROTEIN
KW - TRANSFORMING GROWTH FACTOR-BETA(1)
KW - ANGIOTENSIN-CONVERTING ENZYME
KW - MITRAL ANNULAR CALCIFICATION
KW - CORONARY-ARTERY-DISEASE
KW - HEART-FAILURE
KW - MYOCARDIAL-INFARCTION
KW - INCREASED EXPRESSION
KW - TGF-BETA
KW - MATRICELLULAR PROTEINS
U2 - 10.1016/j.matbio.2020.03.005
DO - 10.1016/j.matbio.2020.03.005
M3 - Review
C2 - 32205152
VL - 91-92
SP - 188
EP - 203
JO - Matrix Biology
JF - Matrix Biology
SN - 0945-053X
IS - SI
ER -
ID: 248497755