ATG16L1: A multifunctional susceptibility factor in Crohn disease

Research output: Contribution to journal › Journal article › Research › peer-review

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ATG16L1 : A multifunctional susceptibility factor in Crohn disease. / Salem, Mohammad; Ammitzboell, Mette; Nys, Kris; Seidelin, Jakob Benedict; Nielsen, Ole Haagen.

In: Autophagy, Vol. 11, No. 4, 03.04.2015, p. 585-94.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Salem, M, Ammitzboell, M, Nys, K, Seidelin, JB & Nielsen, OH 2015, 'ATG16L1: A multifunctional susceptibility factor in Crohn disease', Autophagy, vol. 11, no. 4, pp. 585-94. https://doi.org/10.1080/15548627.2015.1017187

APA

Salem, M., Ammitzboell, M., Nys, K., Seidelin, J. B., & Nielsen, O. H. (2015). ATG16L1: A multifunctional susceptibility factor in Crohn disease. Autophagy, 11(4), 585-94. https://doi.org/10.1080/15548627.2015.1017187

Vancouver

Salem M, Ammitzboell M, Nys K, Seidelin JB, Nielsen OH. ATG16L1: A multifunctional susceptibility factor in Crohn disease. Autophagy. 2015 Apr 3;11(4):585-94. https://doi.org/10.1080/15548627.2015.1017187

Author

Salem, Mohammad ; Ammitzboell, Mette ; Nys, Kris ; Seidelin, Jakob Benedict ; Nielsen, Ole Haagen. / ATG16L1 : A multifunctional susceptibility factor in Crohn disease. In: Autophagy. 2015 ; Vol. 11, No. 4. pp. 585-94.

Bibtex

@article{ddf70f40ce634f4b9f873161b08655cd,
title = "ATG16L1: A multifunctional susceptibility factor in Crohn disease",
abstract = "Genetic variations in the autophagic pathway influence genetic predispositions to Crohn disease. Autophagy, the major lysosomal pathway for degrading and recycling cytoplasmic material, constitutes an important homeostatic cellular process. Of interest, single-nucleotide polymorphisms in ATG16L1 (autophagy-related 16-like 1 [S. cerevisiae]), a key component in the autophagic response to invading pathogens, have been associated with an increased risk of developing Crohn disease. The most common and well-studied genetic variant of ATG16L1 (rs2241880; leading to a T300A conversion) exhibits a strong association with risk for developing Crohn disease. The rs2241880 variant plays a crucial role in pathogen clearance, resulting in imbalanced cytokine production, and is linked to other biological processes, such as the endoplasmic reticulum stress/unfolded protein response. In this review, we focus on the importance of ATG16L1 and its genetic variant (T300A) within the elementary biological processes linked to Crohn disease.",
keywords = "Animals, Autophagy, Carrier Proteins, Crohn Disease, Endoplasmic Reticulum Stress, Genetic Predisposition to Disease, Humans, Polymorphism, Single Nucleotide",
author = "Mohammad Salem and Mette Ammitzboell and Kris Nys and Seidelin, {Jakob Benedict} and Nielsen, {Ole Haagen}",
year = "2015",
month = apr,
day = "3",
doi = "10.1080/15548627.2015.1017187",
language = "English",
volume = "11",
pages = "585--94",
journal = "Autophagy",
issn = "1554-8627",
publisher = "Taylor & Francis",
number = "4",

}

RIS

TY - JOUR

T1 - ATG16L1

T2 - A multifunctional susceptibility factor in Crohn disease

AU - Salem, Mohammad

AU - Ammitzboell, Mette

AU - Nys, Kris

AU - Seidelin, Jakob Benedict

AU - Nielsen, Ole Haagen

PY - 2015/4/3

Y1 - 2015/4/3

N2 - Genetic variations in the autophagic pathway influence genetic predispositions to Crohn disease. Autophagy, the major lysosomal pathway for degrading and recycling cytoplasmic material, constitutes an important homeostatic cellular process. Of interest, single-nucleotide polymorphisms in ATG16L1 (autophagy-related 16-like 1 [S. cerevisiae]), a key component in the autophagic response to invading pathogens, have been associated with an increased risk of developing Crohn disease. The most common and well-studied genetic variant of ATG16L1 (rs2241880; leading to a T300A conversion) exhibits a strong association with risk for developing Crohn disease. The rs2241880 variant plays a crucial role in pathogen clearance, resulting in imbalanced cytokine production, and is linked to other biological processes, such as the endoplasmic reticulum stress/unfolded protein response. In this review, we focus on the importance of ATG16L1 and its genetic variant (T300A) within the elementary biological processes linked to Crohn disease.

AB - Genetic variations in the autophagic pathway influence genetic predispositions to Crohn disease. Autophagy, the major lysosomal pathway for degrading and recycling cytoplasmic material, constitutes an important homeostatic cellular process. Of interest, single-nucleotide polymorphisms in ATG16L1 (autophagy-related 16-like 1 [S. cerevisiae]), a key component in the autophagic response to invading pathogens, have been associated with an increased risk of developing Crohn disease. The most common and well-studied genetic variant of ATG16L1 (rs2241880; leading to a T300A conversion) exhibits a strong association with risk for developing Crohn disease. The rs2241880 variant plays a crucial role in pathogen clearance, resulting in imbalanced cytokine production, and is linked to other biological processes, such as the endoplasmic reticulum stress/unfolded protein response. In this review, we focus on the importance of ATG16L1 and its genetic variant (T300A) within the elementary biological processes linked to Crohn disease.

KW - Animals

KW - Autophagy

KW - Carrier Proteins

KW - Crohn Disease

KW - Endoplasmic Reticulum Stress

KW - Genetic Predisposition to Disease

KW - Humans

KW - Polymorphism, Single Nucleotide

U2 - 10.1080/15548627.2015.1017187

DO - 10.1080/15548627.2015.1017187

M3 - Journal article

C2 - 25906181

VL - 11

SP - 585

EP - 594

JO - Autophagy

JF - Autophagy

SN - 1554-8627

IS - 4

ER -

ID: 159822435