Associations between body mass index trajectories in childhood and cardiovascular risk factors in adulthood
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Associations between body mass index trajectories in childhood and cardiovascular risk factors in adulthood. / Blond, Kim; Aarestrup, Julie; Vistisen, Dorte; Bjerregaard, Lise G.; Jensen, Gorm Boje; Petersen, Janne; Nordestgaard, Børge G.; Jørgensen, Marit E.; Jensen, Britt Wang; Baker, Jennifer L.
In: Atherosclerosis, Vol. 314, 2020, p. 10-17.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Associations between body mass index trajectories in childhood and cardiovascular risk factors in adulthood
AU - Blond, Kim
AU - Aarestrup, Julie
AU - Vistisen, Dorte
AU - Bjerregaard, Lise G.
AU - Jensen, Gorm Boje
AU - Petersen, Janne
AU - Nordestgaard, Børge G.
AU - Jørgensen, Marit E.
AU - Jensen, Britt Wang
AU - Baker, Jennifer L.
PY - 2020
Y1 - 2020
N2 - Background and aims: Children with a growth trajectory of overweight have higher levels of cardiovascular disease (CVD) risk factors than children with a normal-weight trajectory. However, less is known about how trajectories of body mass index (BMI) across the rest of the BMI spectrum relate to CVD risk factors and whether adult BMI affects these associations. Our aim was to examine associations between childhood BMI trajectories and adult CVD risk factors. Methods: We included 2466 individuals with childhood weights and heights (ages 6–14) from the Copenhagen School Health Records Register and adult CVD risk factors (ages 20–81) from the Copenhagen City Heart Study. Associations between childhood BMI trajectories identified by latent class modelling and CVD risk factors were examined using generalized linear regression analyses with and without adjustment for adult BMI. Normal-weight and overweight were defined by growth references from the Centers for Disease Control and Prevention. Results: We identified four childhood trajectories within the normal-weight spectrum and one trajectory of overweight. Compared to the trajectory with the lowest BMI level, several higher BMI trajectories were associated with worse circumference, HDL and glucose homeostasis in adulthood. The highest trajectory was additionally associated with higher total cholesterol and triglycerides. When adjusting for adult BMI, the higher BMI trajectories had lower waist circumference, blood pressure and triglycerides. Conclusions: Trajectories of BMI within the normal-weight range and in the overweight range are associated with a worse CVD risk profile than in the lowest BMI trajectory, and these associations are modifiable by growth after childhood.
AB - Background and aims: Children with a growth trajectory of overweight have higher levels of cardiovascular disease (CVD) risk factors than children with a normal-weight trajectory. However, less is known about how trajectories of body mass index (BMI) across the rest of the BMI spectrum relate to CVD risk factors and whether adult BMI affects these associations. Our aim was to examine associations between childhood BMI trajectories and adult CVD risk factors. Methods: We included 2466 individuals with childhood weights and heights (ages 6–14) from the Copenhagen School Health Records Register and adult CVD risk factors (ages 20–81) from the Copenhagen City Heart Study. Associations between childhood BMI trajectories identified by latent class modelling and CVD risk factors were examined using generalized linear regression analyses with and without adjustment for adult BMI. Normal-weight and overweight were defined by growth references from the Centers for Disease Control and Prevention. Results: We identified four childhood trajectories within the normal-weight spectrum and one trajectory of overweight. Compared to the trajectory with the lowest BMI level, several higher BMI trajectories were associated with worse circumference, HDL and glucose homeostasis in adulthood. The highest trajectory was additionally associated with higher total cholesterol and triglycerides. When adjusting for adult BMI, the higher BMI trajectories had lower waist circumference, blood pressure and triglycerides. Conclusions: Trajectories of BMI within the normal-weight range and in the overweight range are associated with a worse CVD risk profile than in the lowest BMI trajectory, and these associations are modifiable by growth after childhood.
KW - Blood lipids
KW - Blood pressure
KW - Body mass index
KW - Child
KW - Diabetes mellitus
KW - Growth
KW - Obesity
KW - Type 2
U2 - 10.1016/j.atherosclerosis.2020.10.011
DO - 10.1016/j.atherosclerosis.2020.10.011
M3 - Journal article
C2 - 33129081
AN - SCOPUS:85093925392
VL - 314
SP - 10
EP - 17
JO - Journal of atherosclerosis research
JF - Journal of atherosclerosis research
SN - 1567-5688
ER -
ID: 251689313