Are NOD2 polymorphisms linked to a specific disease endophenotype of Crohn's disease?

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Are NOD2 polymorphisms linked to a specific disease endophenotype of Crohn's disease? / Jensen, Stina Rikke; Nielsen, Ole Haagen; Brix, Susanne.

In: Inflammatory Bowel Diseases, Vol. 17, No. 11, 2011, p. 2392-401.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jensen, SR, Nielsen, OH & Brix, S 2011, 'Are NOD2 polymorphisms linked to a specific disease endophenotype of Crohn's disease?', Inflammatory Bowel Diseases, vol. 17, no. 11, pp. 2392-401. https://doi.org/10.1002/ibd.21656

APA

Jensen, S. R., Nielsen, O. H., & Brix, S. (2011). Are NOD2 polymorphisms linked to a specific disease endophenotype of Crohn's disease? Inflammatory Bowel Diseases, 17(11), 2392-401. https://doi.org/10.1002/ibd.21656

Vancouver

Jensen SR, Nielsen OH, Brix S. Are NOD2 polymorphisms linked to a specific disease endophenotype of Crohn's disease? Inflammatory Bowel Diseases. 2011;17(11):2392-401. https://doi.org/10.1002/ibd.21656

Author

Jensen, Stina Rikke ; Nielsen, Ole Haagen ; Brix, Susanne. / Are NOD2 polymorphisms linked to a specific disease endophenotype of Crohn's disease?. In: Inflammatory Bowel Diseases. 2011 ; Vol. 17, No. 11. pp. 2392-401.

Bibtex

@article{d8871e1eaa264fb3a428c7ce99582418,
title = "Are NOD2 polymorphisms linked to a specific disease endophenotype of Crohn's disease?",
abstract = "The complex and yet unknown etiology of Crohn's disease (CD) might consist of various disease endophenotypes, each of which represent their own pathogenesis. This review focuses on the disease endophenotype linked to polymorphisms in the nucleotide-binding oligomerization domain containing 2 (NOD2) protein and on the importance of established adherent-invasive E. coli (AIEC) in ileal mucosa. To date, there are several reports pointing to the implications of NOD2 polymorphisms in epithelial and immunological responses against microbes, but the pathological significance of NOD2 mutations in CD is not yet clarified. The enhanced number of pathogenic E. coli in the ileal mucosa of CD as compared to healthy controls may result from a genetically based failure in one of the intestinal bacteria sensing systems, like NOD2, making the ileal epithelium more prone to colonization with microbes harboring specific properties such as AIEC. Increasing the focus on defining subgroups of patients with similar disease initiations, mechanisms of action, and manifestations in CD may be pivotal for the development and implementation of future individualized treatment strategies of benefit for the single patient at an early stage.",
author = "Jensen, {Stina Rikke} and Nielsen, {Ole Haagen} and Susanne Brix",
note = "Copyright {\textcopyright} 2011 Crohn's & Crohn's & Colitis Foundation of America, Inc.",
year = "2011",
doi = "http://dx.doi.org/10.1002/ibd.21656",
language = "English",
volume = "17",
pages = "2392--401",
journal = "Inflammatory Bowel Diseases",
issn = "1078-0998",
publisher = "Lippincott Williams & Wilkins",
number = "11",

}

RIS

TY - JOUR

T1 - Are NOD2 polymorphisms linked to a specific disease endophenotype of Crohn's disease?

AU - Jensen, Stina Rikke

AU - Nielsen, Ole Haagen

AU - Brix, Susanne

N1 - Copyright © 2011 Crohn's & Crohn's & Colitis Foundation of America, Inc.

PY - 2011

Y1 - 2011

N2 - The complex and yet unknown etiology of Crohn's disease (CD) might consist of various disease endophenotypes, each of which represent their own pathogenesis. This review focuses on the disease endophenotype linked to polymorphisms in the nucleotide-binding oligomerization domain containing 2 (NOD2) protein and on the importance of established adherent-invasive E. coli (AIEC) in ileal mucosa. To date, there are several reports pointing to the implications of NOD2 polymorphisms in epithelial and immunological responses against microbes, but the pathological significance of NOD2 mutations in CD is not yet clarified. The enhanced number of pathogenic E. coli in the ileal mucosa of CD as compared to healthy controls may result from a genetically based failure in one of the intestinal bacteria sensing systems, like NOD2, making the ileal epithelium more prone to colonization with microbes harboring specific properties such as AIEC. Increasing the focus on defining subgroups of patients with similar disease initiations, mechanisms of action, and manifestations in CD may be pivotal for the development and implementation of future individualized treatment strategies of benefit for the single patient at an early stage.

AB - The complex and yet unknown etiology of Crohn's disease (CD) might consist of various disease endophenotypes, each of which represent their own pathogenesis. This review focuses on the disease endophenotype linked to polymorphisms in the nucleotide-binding oligomerization domain containing 2 (NOD2) protein and on the importance of established adherent-invasive E. coli (AIEC) in ileal mucosa. To date, there are several reports pointing to the implications of NOD2 polymorphisms in epithelial and immunological responses against microbes, but the pathological significance of NOD2 mutations in CD is not yet clarified. The enhanced number of pathogenic E. coli in the ileal mucosa of CD as compared to healthy controls may result from a genetically based failure in one of the intestinal bacteria sensing systems, like NOD2, making the ileal epithelium more prone to colonization with microbes harboring specific properties such as AIEC. Increasing the focus on defining subgroups of patients with similar disease initiations, mechanisms of action, and manifestations in CD may be pivotal for the development and implementation of future individualized treatment strategies of benefit for the single patient at an early stage.

U2 - http://dx.doi.org/10.1002/ibd.21656

DO - http://dx.doi.org/10.1002/ibd.21656

M3 - Journal article

VL - 17

SP - 2392

EP - 2401

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

SN - 1078-0998

IS - 11

ER -

ID: 40182414