Antidepressant Fluoxetine Does Not Appear to Interfere With Key Translational Parameters in the Rat Adjuvant-induced Arthritis Model
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Antidepressant Fluoxetine Does Not Appear to Interfere With Key Translational Parameters in the Rat Adjuvant-induced Arthritis Model. / Seveljevic-Jaran, Dasa; Kalliokoski, Otto; Abelson, Klas S.P.; Hau, Jann.
In: In Vivo, Vol. 36, No. 2, 2022, p. 635-642.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Antidepressant Fluoxetine Does Not Appear to Interfere With Key Translational Parameters in the Rat Adjuvant-induced Arthritis Model
AU - Seveljevic-Jaran, Dasa
AU - Kalliokoski, Otto
AU - Abelson, Klas S.P.
AU - Hau, Jann
N1 - Publisher Copyright: Copyright © 2022, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
PY - 2022
Y1 - 2022
N2 - BACKGROUND/AIM: This study aimed to investigate the analgesic effects of fluoxetine on Lewis rats of both sexes in the adjuvant-induced arthritis (AIA) rat model. In humans, chronic pain syndromes typical of rheumatoid arthritis (RA) co-exist with depression which is often treated with fluoxetine antidepressant known to have antinociceptive effects. MATERIALS AND METHODS: The experiment was terminated on day 26, after seven days of oral treatment (days 19-25) with fluoxetine and indomethacin. The effects of treatments were assessed on the final day of the study through measuring body weight, serum concentrations of a1-acid glycoprotein, visual arthritis assessment and post mortem histopathology assessment. RESULTS: Statistically significant difference was determined in the body weight of male subjects, with indomethacin-treated animals putting on significantly more weight than the vehicle and fluoxetine-treated counterparts. No differences were found between the different treatment groups in other study assessments. CONCLUSION: The present study did not provide support for analgesic effects of fluoxetine aimed at reducing the severity of the AIA model.
AB - BACKGROUND/AIM: This study aimed to investigate the analgesic effects of fluoxetine on Lewis rats of both sexes in the adjuvant-induced arthritis (AIA) rat model. In humans, chronic pain syndromes typical of rheumatoid arthritis (RA) co-exist with depression which is often treated with fluoxetine antidepressant known to have antinociceptive effects. MATERIALS AND METHODS: The experiment was terminated on day 26, after seven days of oral treatment (days 19-25) with fluoxetine and indomethacin. The effects of treatments were assessed on the final day of the study through measuring body weight, serum concentrations of a1-acid glycoprotein, visual arthritis assessment and post mortem histopathology assessment. RESULTS: Statistically significant difference was determined in the body weight of male subjects, with indomethacin-treated animals putting on significantly more weight than the vehicle and fluoxetine-treated counterparts. No differences were found between the different treatment groups in other study assessments. CONCLUSION: The present study did not provide support for analgesic effects of fluoxetine aimed at reducing the severity of the AIA model.
KW - analgesia
KW - fluoxetine
KW - rat model
KW - Rheumatoid arthritis
U2 - 10.21873/invivo.12747
DO - 10.21873/invivo.12747
M3 - Journal article
C2 - 35241516
AN - SCOPUS:85125690601
VL - 36
SP - 635
EP - 642
JO - In Vivo
JF - In Vivo
SN - 0258-851X
IS - 2
ER -
ID: 300066186