Anthropometrics and prognosis in diffuse large B-cell lymphoma: a multicentre study of 653 patients

Research output: Contribution to journalJournal articleResearchpeer-review

  • Mette Dahl Bendtsen
  • Peter Svenssen Munksgaard
  • Marianne Tang Severinsen
  • Eric Bekric
  • Christian Brieghel
  • Kristina Buchardi Nielsen
  • Brown, Peter de Nully
  • Karen Dybkær
  • Hans Erik Johnsen
  • Martin Bøgsted
  • Tarec Christoffer El-Galaly

Objective: The impact of body mass index (BMI) and body surface area (BSA) on survival in diffuse large B-cell lymphoma (DLBCL) is controversial. Recent studies show superior outcomes for overweight and obese patients. Patients and methods: A total of 653 R-CHOP(-like)-treated DLBCL patients were included in this retrospective cohort study. Patients, baseline clinicopathologic characteristics and treatment information were retrieved from the Danish Lymphoma Registry. Anthropometric measures were obtained from chemotherapy prescription charts. Results: Underweight (BMI <18.5 kg/m2) was associated with significantly worse progression-free survival (PFS) for male patients only in sex-stratified analyses (HR 3.92, 95% CI: 1.57–9.75, P = 0.003, for males; HR 1.65, 95% CI: 0.90–3.02, P = 0.107, for females). In multivariate analyses, underweight was associated with worse PFS for both sexes (HR 5.34, 95% CI: 2.07–13.79, P = 0.001, for males; HR 2.14, 95% CI: 1.12–4.08, P = 0.021, for females). Similar results were obtained in analyses of overall survival. In crude analyses, BSA <1.8 m2 was associated with worse PFS for men and women (HR 1.65, 95% CI: 1.03–2.65, P = 0.039, for men; HR 1.62, 95% CI: 1.03–2.56, P = 0.037, for women). In multivariate analyses, however, these associations diminished. Conclusions: Our study demonstrates that underweight DLBCL patients have worse outcomes following R-CHOP as compared to normal as well as overweight patients.

Original languageEnglish
JournalEuropean Journal of Haematology
Issue number4
Pages (from-to)355-362
Publication statusPublished - 2017

    Research areas

  • body mass index, body surface area, diffuse large B-cell lymphoma, prognosis, survival

ID: 189628825