Annexin A7 is required for ESCRT III-mediated plasma membrane repair

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Annexin A7 is required for ESCRT III-mediated plasma membrane repair. / Sønder, Stine Lauritzen; Boye, Theresa Louise; Tölle, Regine; Dengjel, Jörn; Maeda, Kenji; Jäättelä, Marja; Simonsen, Adam Cohen; Jaiswal, Jyoti K.; Nylandsted, Jesper.

In: Scientific Reports, Vol. 9, No. 1, 6726, 2019.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sønder, SL, Boye, TL, Tölle, R, Dengjel, J, Maeda, K, Jäättelä, M, Simonsen, AC, Jaiswal, JK & Nylandsted, J 2019, 'Annexin A7 is required for ESCRT III-mediated plasma membrane repair', Scientific Reports, vol. 9, no. 1, 6726. https://doi.org/10.1038/s41598-019-43143-4

APA

Sønder, S. L., Boye, T. L., Tölle, R., Dengjel, J., Maeda, K., Jäättelä, M., Simonsen, A. C., Jaiswal, J. K., & Nylandsted, J. (2019). Annexin A7 is required for ESCRT III-mediated plasma membrane repair. Scientific Reports, 9(1), [6726]. https://doi.org/10.1038/s41598-019-43143-4

Vancouver

Sønder SL, Boye TL, Tölle R, Dengjel J, Maeda K, Jäättelä M et al. Annexin A7 is required for ESCRT III-mediated plasma membrane repair. Scientific Reports. 2019;9(1). 6726. https://doi.org/10.1038/s41598-019-43143-4

Author

Sønder, Stine Lauritzen ; Boye, Theresa Louise ; Tölle, Regine ; Dengjel, Jörn ; Maeda, Kenji ; Jäättelä, Marja ; Simonsen, Adam Cohen ; Jaiswal, Jyoti K. ; Nylandsted, Jesper. / Annexin A7 is required for ESCRT III-mediated plasma membrane repair. In: Scientific Reports. 2019 ; Vol. 9, No. 1.

Bibtex

@article{fc6add51ebd84d1c90807d59768558c5,
title = "Annexin A7 is required for ESCRT III-mediated plasma membrane repair",
abstract = " The plasma membrane of eukaryotic cells forms the essential barrier to the extracellular environment, and thus plasma membrane disruptions pose a fatal threat to cells. Here, using invasive breast cancer cells we show that the Ca 2+ - and phospholipid-binding protein annexin A7 is part of the plasma membrane repair response by enabling assembly of the endosomal sorting complex required for transport (ESCRT) III. Following injury to the plasma membrane and Ca 2+ flux into the cytoplasm, annexin A7 forms a complex with apoptosis linked gene-2 (ALG-2) to facilitate proper recruitment and binding of ALG-2 and ALG-2-interacting protein X (ALIX) to the damaged membrane. ALG-2 and ALIX assemble the ESCRT III complex, which helps excise and shed the damaged portion of the plasma membrane during wound healing. Our results reveal a novel function of annexin A7 – enabling plasma membrane repair by regulating ESCRT III-mediated shedding of injured plasma membrane. ",
author = "S{\o}nder, {Stine Lauritzen} and Boye, {Theresa Louise} and Regine T{\"o}lle and J{\"o}rn Dengjel and Kenji Maeda and Marja J{\"a}{\"a}ttel{\"a} and Simonsen, {Adam Cohen} and Jaiswal, {Jyoti K.} and Jesper Nylandsted",
year = "2019",
doi = "10.1038/s41598-019-43143-4",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Annexin A7 is required for ESCRT III-mediated plasma membrane repair

AU - Sønder, Stine Lauritzen

AU - Boye, Theresa Louise

AU - Tölle, Regine

AU - Dengjel, Jörn

AU - Maeda, Kenji

AU - Jäättelä, Marja

AU - Simonsen, Adam Cohen

AU - Jaiswal, Jyoti K.

AU - Nylandsted, Jesper

PY - 2019

Y1 - 2019

N2 - The plasma membrane of eukaryotic cells forms the essential barrier to the extracellular environment, and thus plasma membrane disruptions pose a fatal threat to cells. Here, using invasive breast cancer cells we show that the Ca 2+ - and phospholipid-binding protein annexin A7 is part of the plasma membrane repair response by enabling assembly of the endosomal sorting complex required for transport (ESCRT) III. Following injury to the plasma membrane and Ca 2+ flux into the cytoplasm, annexin A7 forms a complex with apoptosis linked gene-2 (ALG-2) to facilitate proper recruitment and binding of ALG-2 and ALG-2-interacting protein X (ALIX) to the damaged membrane. ALG-2 and ALIX assemble the ESCRT III complex, which helps excise and shed the damaged portion of the plasma membrane during wound healing. Our results reveal a novel function of annexin A7 – enabling plasma membrane repair by regulating ESCRT III-mediated shedding of injured plasma membrane.

AB - The plasma membrane of eukaryotic cells forms the essential barrier to the extracellular environment, and thus plasma membrane disruptions pose a fatal threat to cells. Here, using invasive breast cancer cells we show that the Ca 2+ - and phospholipid-binding protein annexin A7 is part of the plasma membrane repair response by enabling assembly of the endosomal sorting complex required for transport (ESCRT) III. Following injury to the plasma membrane and Ca 2+ flux into the cytoplasm, annexin A7 forms a complex with apoptosis linked gene-2 (ALG-2) to facilitate proper recruitment and binding of ALG-2 and ALG-2-interacting protein X (ALIX) to the damaged membrane. ALG-2 and ALIX assemble the ESCRT III complex, which helps excise and shed the damaged portion of the plasma membrane during wound healing. Our results reveal a novel function of annexin A7 – enabling plasma membrane repair by regulating ESCRT III-mediated shedding of injured plasma membrane.

U2 - 10.1038/s41598-019-43143-4

DO - 10.1038/s41598-019-43143-4

M3 - Journal article

C2 - 31040365

AN - SCOPUS:85064905404

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 6726

ER -

ID: 226352667