An online GPCR structure analysis platform

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We present an online, interactive platform for comparative analysis of all available G-protein coupled receptor (GPCR) structures while correlating to functional data. The comprehensive platform encompasses structure similarity, secondary structure, protein backbone packing and movement, residue–residue contact networks, amino acid properties and prospective design of experimental mutagenesis studies. This lets any researcher tap the potential of sophisticated structural analyses enabling a plethora of basic and applied receptor research studies.

Original languageEnglish
JournalNature Structural and Molecular Biology
Issue number11
Pages (from-to)875-878
Publication statusPublished - 2021

Bibliographical note

Funding Information:
This work was supported by the Lundbeck Foundation (grant nos R163-2013-16327 and R218-2016-1266), the Novo Nordisk Foundation (grant no NNF18OC0031226) and Independent Research Fund Denmark | Natural Sciences (grant no 8021-00173B) to D.E.G.

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.

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