Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model. / Sattler, Stefan M.; Lubberding, Anniek F.; Skibsbye, Lasse; Jabbari, Reza; Wakili, Reza; Jespersen, Thomas; Tfelt-Hansen, Jacob.

In: Journal of Cardiovascular Translational Research, Vol. 12, No. 4, 2019, p. 321-330 .

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sattler, SM, Lubberding, AF, Skibsbye, L, Jabbari, R, Wakili, R, Jespersen, T & Tfelt-Hansen, J 2019, 'Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model', Journal of Cardiovascular Translational Research, vol. 12, no. 4, pp. 321-330 . https://doi.org/10.1007/s12265-018-9861-6

APA

Sattler, S. M., Lubberding, A. F., Skibsbye, L., Jabbari, R., Wakili, R., Jespersen, T., & Tfelt-Hansen, J. (2019). Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model. Journal of Cardiovascular Translational Research, 12(4), 321-330 . https://doi.org/10.1007/s12265-018-9861-6

Vancouver

Sattler SM, Lubberding AF, Skibsbye L, Jabbari R, Wakili R, Jespersen T et al. Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model. Journal of Cardiovascular Translational Research. 2019;12(4):321-330 . https://doi.org/10.1007/s12265-018-9861-6

Author

Sattler, Stefan M. ; Lubberding, Anniek F. ; Skibsbye, Lasse ; Jabbari, Reza ; Wakili, Reza ; Jespersen, Thomas ; Tfelt-Hansen, Jacob. / Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model. In: Journal of Cardiovascular Translational Research. 2019 ; Vol. 12, No. 4. pp. 321-330 .

Bibtex

@article{8fe04cd5c4e9470fb4d59a87ede474bf,
title = "Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model",
abstract = "Ventricular fibrillation (VF) occurring in the first minutes to hours of acute myocardial infarction (AMI) is a frequent cause of death and treatment options are limited. The aim was to test whether early infusion of amiodarone 10 min after onset of AMI reduced the incidence of VF in a porcine model. Eighteen female Danish landrace pigs were randomized to a control and an amiodarone group. AMI was induced by ligation of the mid-left anterior descending artery for 120 min followed by 60 min of reperfusion. VF occurred in 0/8 pigs treated with amiodarone compared to 7/10 controls (P < 0.01). Amiodarone treatment prolonged RR intervals, reduced dispersion of action potential duration in the infarcted area and mean number of ectopic beats. No negative effects on cardiac output and blood pressure were observed with amiodarone. Amiodarone qualifies as a potential drug candidate to prevent VF in the first minutes to hours of AMI.",
keywords = "Acute myocardial infarction, Amiodarone, Animal model, Sudden cardiac death, Ventricular fibrillation",
author = "Sattler, {Stefan M.} and Lubberding, {Anniek F.} and Lasse Skibsbye and Reza Jabbari and Reza Wakili and Thomas Jespersen and Jacob Tfelt-Hansen",
year = "2019",
doi = "10.1007/s12265-018-9861-6",
language = "English",
volume = "12",
pages = "321--330 ",
journal = "Journal of Cardiovascular Translational Research",
issn = "1937-5387",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model

AU - Sattler, Stefan M.

AU - Lubberding, Anniek F.

AU - Skibsbye, Lasse

AU - Jabbari, Reza

AU - Wakili, Reza

AU - Jespersen, Thomas

AU - Tfelt-Hansen, Jacob

PY - 2019

Y1 - 2019

N2 - Ventricular fibrillation (VF) occurring in the first minutes to hours of acute myocardial infarction (AMI) is a frequent cause of death and treatment options are limited. The aim was to test whether early infusion of amiodarone 10 min after onset of AMI reduced the incidence of VF in a porcine model. Eighteen female Danish landrace pigs were randomized to a control and an amiodarone group. AMI was induced by ligation of the mid-left anterior descending artery for 120 min followed by 60 min of reperfusion. VF occurred in 0/8 pigs treated with amiodarone compared to 7/10 controls (P < 0.01). Amiodarone treatment prolonged RR intervals, reduced dispersion of action potential duration in the infarcted area and mean number of ectopic beats. No negative effects on cardiac output and blood pressure were observed with amiodarone. Amiodarone qualifies as a potential drug candidate to prevent VF in the first minutes to hours of AMI.

AB - Ventricular fibrillation (VF) occurring in the first minutes to hours of acute myocardial infarction (AMI) is a frequent cause of death and treatment options are limited. The aim was to test whether early infusion of amiodarone 10 min after onset of AMI reduced the incidence of VF in a porcine model. Eighteen female Danish landrace pigs were randomized to a control and an amiodarone group. AMI was induced by ligation of the mid-left anterior descending artery for 120 min followed by 60 min of reperfusion. VF occurred in 0/8 pigs treated with amiodarone compared to 7/10 controls (P < 0.01). Amiodarone treatment prolonged RR intervals, reduced dispersion of action potential duration in the infarcted area and mean number of ectopic beats. No negative effects on cardiac output and blood pressure were observed with amiodarone. Amiodarone qualifies as a potential drug candidate to prevent VF in the first minutes to hours of AMI.

KW - Acute myocardial infarction

KW - Amiodarone

KW - Animal model

KW - Sudden cardiac death

KW - Ventricular fibrillation

U2 - 10.1007/s12265-018-9861-6

DO - 10.1007/s12265-018-9861-6

M3 - Journal article

C2 - 30617762

AN - SCOPUS:85059606817

VL - 12

SP - 321

EP - 330

JO - Journal of Cardiovascular Translational Research

JF - Journal of Cardiovascular Translational Research

SN - 1937-5387

IS - 4

ER -

ID: 216210976