Amino acids: Glutamate dehydrogenase: An anaplerotic enzyme in neurons and an energy producing enzyme in astrocytes

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

Amino acids : Glutamate dehydrogenase: An anaplerotic enzyme in neurons and an energy producing enzyme in astrocytes. / Schousboe, Arne; Aldana, Blanca I.

Encyclopedia of Biological Chemistry: Third Edition. Vol. 1 Elsevier, 2021. p. 51-55.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Schousboe, A & Aldana, BI 2021, Amino acids: Glutamate dehydrogenase: An anaplerotic enzyme in neurons and an energy producing enzyme in astrocytes. in Encyclopedia of Biological Chemistry: Third Edition. vol. 1, Elsevier, pp. 51-55. https://doi.org/10.1016/B978-0-12-809633-8.21361-7

APA

Schousboe, A., & Aldana, B. I. (2021). Amino acids: Glutamate dehydrogenase: An anaplerotic enzyme in neurons and an energy producing enzyme in astrocytes. In Encyclopedia of Biological Chemistry: Third Edition (Vol. 1, pp. 51-55). Elsevier. https://doi.org/10.1016/B978-0-12-809633-8.21361-7

Vancouver

Schousboe A, Aldana BI. Amino acids: Glutamate dehydrogenase: An anaplerotic enzyme in neurons and an energy producing enzyme in astrocytes. In Encyclopedia of Biological Chemistry: Third Edition. Vol. 1. Elsevier. 2021. p. 51-55 https://doi.org/10.1016/B978-0-12-809633-8.21361-7

Author

Schousboe, Arne ; Aldana, Blanca I. / Amino acids : Glutamate dehydrogenase: An anaplerotic enzyme in neurons and an energy producing enzyme in astrocytes. Encyclopedia of Biological Chemistry: Third Edition. Vol. 1 Elsevier, 2021. pp. 51-55

Bibtex

@inbook{a027cb3fbb674901a612230a4a964f97,
title = "Amino acids: Glutamate dehydrogenase: An anaplerotic enzyme in neurons and an energy producing enzyme in astrocytes",
abstract = "The enzyme glutamate dehydrogenase (GDH) catalyzes the interconversion of glutamate and α-ketoglutarate using NAD(P)+/NAD(P)H + H+ as the coenzyme in the redox process. Under physiological conditions in the brain the reaction proceeds as an oxidative conversion of glutamate to α-ketoglutarate. In neurons that do not express the anaplerotic enzyme pyruvate carboxylase the GDH reaction can provide the TCA cycle with the intermediate α-ketoglutarate thus acting as an anaplerotic enzyme ameliorating any drain of TCA cycle intermediates. As astrocytes express the alternative anaplerotic enzyme, pyruvate carboxylase the GDH catalyzed process is of less importance for anaplerosis in these cells. However, in the astrocytes the GDH enzyme appears to be of importance in energy production via the TCA cycle and oxidative phosphorylation as well as a means to enhance TCA cycle capacity facilitating oxidative glucose metabolism. The main text will provide detailed discussions of these different scenarios.",
author = "Arne Schousboe and Aldana, {Blanca I.}",
year = "2021",
month = jul,
day = "29",
doi = "10.1016/B978-0-12-809633-8.21361-7",
language = "English",
isbn = "9780128194607",
volume = "1",
pages = "51--55",
booktitle = "Encyclopedia of Biological Chemistry",
publisher = "Elsevier",

}

RIS

TY - CHAP

T1 - Amino acids

T2 - Glutamate dehydrogenase: An anaplerotic enzyme in neurons and an energy producing enzyme in astrocytes

AU - Schousboe, Arne

AU - Aldana, Blanca I.

PY - 2021/7/29

Y1 - 2021/7/29

N2 - The enzyme glutamate dehydrogenase (GDH) catalyzes the interconversion of glutamate and α-ketoglutarate using NAD(P)+/NAD(P)H + H+ as the coenzyme in the redox process. Under physiological conditions in the brain the reaction proceeds as an oxidative conversion of glutamate to α-ketoglutarate. In neurons that do not express the anaplerotic enzyme pyruvate carboxylase the GDH reaction can provide the TCA cycle with the intermediate α-ketoglutarate thus acting as an anaplerotic enzyme ameliorating any drain of TCA cycle intermediates. As astrocytes express the alternative anaplerotic enzyme, pyruvate carboxylase the GDH catalyzed process is of less importance for anaplerosis in these cells. However, in the astrocytes the GDH enzyme appears to be of importance in energy production via the TCA cycle and oxidative phosphorylation as well as a means to enhance TCA cycle capacity facilitating oxidative glucose metabolism. The main text will provide detailed discussions of these different scenarios.

AB - The enzyme glutamate dehydrogenase (GDH) catalyzes the interconversion of glutamate and α-ketoglutarate using NAD(P)+/NAD(P)H + H+ as the coenzyme in the redox process. Under physiological conditions in the brain the reaction proceeds as an oxidative conversion of glutamate to α-ketoglutarate. In neurons that do not express the anaplerotic enzyme pyruvate carboxylase the GDH reaction can provide the TCA cycle with the intermediate α-ketoglutarate thus acting as an anaplerotic enzyme ameliorating any drain of TCA cycle intermediates. As astrocytes express the alternative anaplerotic enzyme, pyruvate carboxylase the GDH catalyzed process is of less importance for anaplerosis in these cells. However, in the astrocytes the GDH enzyme appears to be of importance in energy production via the TCA cycle and oxidative phosphorylation as well as a means to enhance TCA cycle capacity facilitating oxidative glucose metabolism. The main text will provide detailed discussions of these different scenarios.

U2 - 10.1016/B978-0-12-809633-8.21361-7

DO - 10.1016/B978-0-12-809633-8.21361-7

M3 - Book chapter

AN - SCOPUS:85118524488

SN - 9780128194607

VL - 1

SP - 51

EP - 55

BT - Encyclopedia of Biological Chemistry

PB - Elsevier

ER -

ID: 346538700