Alu Elements as Novel Regulators of Gene Expression in Type 1 Diabetes Susceptibility Genes?

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Alu Elements as Novel Regulators of Gene Expression in Type 1 Diabetes Susceptibility Genes? / Kaur, Simranjeet; Pociot, Flemming.

In: Genes, Vol. 6, No. 3, 2015, p. 577-91.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kaur, S & Pociot, F 2015, 'Alu Elements as Novel Regulators of Gene Expression in Type 1 Diabetes Susceptibility Genes?', Genes, vol. 6, no. 3, pp. 577-91. https://doi.org/10.3390/genes6030577

APA

Kaur, S., & Pociot, F. (2015). Alu Elements as Novel Regulators of Gene Expression in Type 1 Diabetes Susceptibility Genes? Genes, 6(3), 577-91. https://doi.org/10.3390/genes6030577

Vancouver

Kaur S, Pociot F. Alu Elements as Novel Regulators of Gene Expression in Type 1 Diabetes Susceptibility Genes? Genes. 2015;6(3):577-91. https://doi.org/10.3390/genes6030577

Author

Kaur, Simranjeet ; Pociot, Flemming. / Alu Elements as Novel Regulators of Gene Expression in Type 1 Diabetes Susceptibility Genes?. In: Genes. 2015 ; Vol. 6, No. 3. pp. 577-91.

Bibtex

@article{30e99720bf5145a6b704b512ab623dc9,
title = "Alu Elements as Novel Regulators of Gene Expression in Type 1 Diabetes Susceptibility Genes?",
abstract = "Despite numerous studies implicating Alu repeat elements in various diseases, there is sparse information available with respect to the potential functional and biological roles of the repeat elements in Type 1 diabetes (T1D). Therefore, we performed a genome-wide sequence analysis of T1D candidate genes to identify embedded Alu elements within these genes. We observed significant enrichment of Alu elements within the T1D genes (p-value < 10e-16), which highlights their importance in T1D. Functional annotation of T1D genes harboring Alus revealed significant enrichment for immune-mediated processes (p-value < 10e-6). We also identified eight T1D genes harboring inverted Alus (IRAlus) within their 3' untranslated regions (UTRs) that are known to regulate the expression of host mRNAs by generating double stranded RNA duplexes. Our in silico analysis predicted the formation of duplex structures by IRAlus within the 3'UTRs of T1D genes. We propose that IRAlus might be involved in regulating the expression levels of the host T1D genes.",
author = "Simranjeet Kaur and Flemming Pociot",
year = "2015",
doi = "10.3390/genes6030577",
language = "English",
volume = "6",
pages = "577--91",
journal = "Genes",
issn = "2073-4425",
publisher = "M D P I AG",
number = "3",

}

RIS

TY - JOUR

T1 - Alu Elements as Novel Regulators of Gene Expression in Type 1 Diabetes Susceptibility Genes?

AU - Kaur, Simranjeet

AU - Pociot, Flemming

PY - 2015

Y1 - 2015

N2 - Despite numerous studies implicating Alu repeat elements in various diseases, there is sparse information available with respect to the potential functional and biological roles of the repeat elements in Type 1 diabetes (T1D). Therefore, we performed a genome-wide sequence analysis of T1D candidate genes to identify embedded Alu elements within these genes. We observed significant enrichment of Alu elements within the T1D genes (p-value < 10e-16), which highlights their importance in T1D. Functional annotation of T1D genes harboring Alus revealed significant enrichment for immune-mediated processes (p-value < 10e-6). We also identified eight T1D genes harboring inverted Alus (IRAlus) within their 3' untranslated regions (UTRs) that are known to regulate the expression of host mRNAs by generating double stranded RNA duplexes. Our in silico analysis predicted the formation of duplex structures by IRAlus within the 3'UTRs of T1D genes. We propose that IRAlus might be involved in regulating the expression levels of the host T1D genes.

AB - Despite numerous studies implicating Alu repeat elements in various diseases, there is sparse information available with respect to the potential functional and biological roles of the repeat elements in Type 1 diabetes (T1D). Therefore, we performed a genome-wide sequence analysis of T1D candidate genes to identify embedded Alu elements within these genes. We observed significant enrichment of Alu elements within the T1D genes (p-value < 10e-16), which highlights their importance in T1D. Functional annotation of T1D genes harboring Alus revealed significant enrichment for immune-mediated processes (p-value < 10e-6). We also identified eight T1D genes harboring inverted Alus (IRAlus) within their 3' untranslated regions (UTRs) that are known to regulate the expression of host mRNAs by generating double stranded RNA duplexes. Our in silico analysis predicted the formation of duplex structures by IRAlus within the 3'UTRs of T1D genes. We propose that IRAlus might be involved in regulating the expression levels of the host T1D genes.

U2 - 10.3390/genes6030577

DO - 10.3390/genes6030577

M3 - Journal article

C2 - 26184322

VL - 6

SP - 577

EP - 591

JO - Genes

JF - Genes

SN - 2073-4425

IS - 3

ER -

ID: 161846675