Alteration in pancreatic islet function in human immunodeficiency virus
Research output: Contribution to journal › Journal article › Research › peer-review
Molecular mechanisms behind the defects in insulin production and secretion associated with antihuman immunodeficiency virus (anti-HIV) therapy and the development of HIV-associated lipodystrophy syndrome (HALS) are discussed in this article. Data suggesting insulin resistance on the beta cell and defects in first-phase insulin release of HALS patients are presented. Hepatic extraction of insulin, nonglucose insulin secretagogues and insulin-like growth factor release may exert influence on the demand of circulating insulin and on insulin secretion in HIV-infected patients. Finally, the paucity in understanding the incretin effects in HIV and HIV therapy in relation to insulin secretion is highlighted.
Original language | English |
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Journal | Endocrinology & Metabolism Clinics of North America |
Volume | 43 |
Issue number | 3 |
Pages (from-to) | 697-708 |
Number of pages | 12 |
ISSN | 0889-8529 |
DOIs | |
Publication status | Published - Sep 2014 |
- Carbamates, HIV Protease Inhibitors, HIV-Associated Lipodystrophy Syndrome, Humans, Indinavir, Insulin, Insulin Resistance, Insulin-Secreting Cells, Nelfinavir, Ritonavir, Sulfonamides
Research areas
ID: 137909420