Aliphatic 18F-Radiofluorination: Recent Advances in the Labeling of Base-Sensitive Substrates**
Research output: Contribution to journal › Review › Research › peer-review
Aliphatic fluorine-18 radiolabeling is the most commonly used method to synthesize tracers for PET-imaging. With an increasing demand for 18F-radiotracers for clinical applications, new labeling strategies aiming to increase radiochemical yields of established tracers or, more importantly, to enable 18F-labeling of new scaffolds have been developed. In recent years, increased attention has been focused on the direct aliphatic 18F-fluorination of base-sensitive substrates in this respect. This minireview gives a concise overview of the recent advances within this field and aims to highlight the advantages and limitations of these methods.
Original language | English |
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Journal | ChemMedChem |
Volume | 16 |
Issue number | 17 |
Pages (from-to) | 2612-2622 |
ISSN | 1860-7179 |
DOIs | |
Publication status | Published - 2021 |
Bibliographical note
Funding Information:
This work was supported by BRIDGE – Translational Excellence Program at the Faculty of Health and Medical Sciences, University of Copenhagen, funded by the Novo Nordisk Foundation (grant agreement no. NNF18SA0034956). The Lundbeck Foundation, the Innovation Fund Denmark, and the Research Council for Independent Research are further acknowledged. We would also like to acknowledge Maria Erlandsson, Tomas Ohlsson and Nic Gillings for good discussions and support in writing this manuscript.
- aliphatic, base sensitivity, fluorine-18, radiochemistry, S2
Research areas
ID: 281708809