Airway hyperresponsiveness and development of lung function in adolescence and adulthood

Research output: Contribution to journalJournal articleResearchpeer-review

BACKGROUND: Long-term longitudinal studies of lung function from childhood to adulthood are important in linking our understanding of childhood risk factors to adult disease. Airway hyperresponsiveness has been shown to independently affect lung function growth in studies of adolescence. The objective of the study was to test the hypothesis that airway hyperresponsiveness has an independent deleterious effect on lung function in adolescence that extends into adulthood.

METHODS: A random population sample (n = 983) aged 7-17 from Copenhagen was followed longitudinally for 20 years with four examinations.

RESULTS: A total of 780 (79.3%) subjects contributed with lung function measurements and bronchial provocation testing. Among these, 170 (21.8%) had airway hyperresponsiveness at one examination or more during the study period. There was no difference in initial FEV1 levels between subjects with and without airway hyperresponsiveness. In a repeated measures regression model with adjustment for asthma and smoking, airway hyperresponsiveness was independently associated with reduced rates of growth in lung function in both sexes of 23 ml/year. Reduced growth rates resulted in deficits in maximal attained level of lung function at age 18, which persisted throughout the follow-up until the last examination at age 27-37 years.

CONCLUSION: Airway hyperresponsiveness has an independent deleterious effect on lung function development from 7 to 37 years resulting in a lower maximal attained lung function and persistent deficits in lung function in adulthood.

Original languageEnglish
JournalRespiratory Medicine
Issue number5
Pages (from-to)752-757
Number of pages6
Publication statusPublished - 2014

    Research areas

  • Adolescent, Aging, Asthma, Bronchial Hyperreactivity, Bronchial Provocation Tests, Child, Female, Forced Expiratory Volume, Humans, Longitudinal Studies, Lung, Male, Respiratory Function Tests, Smoking, Vital Capacity

ID: 137670546