Ageing is associated with diminished muscle re-growth and myogenic precursor cell expansion early after immobility-induced atrophy in human skeletal muscle

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Ageing is associated with diminished muscle re-growth and myogenic precursor cell expansion early after immobility-induced atrophy in human skeletal muscle. / Suetta, C.; Frandsen, Ulrik; Mackey, Abigail; Jensen, L.; Hvid, L. G.; Bayer, M.L.; Petersson, Stine Juhl; Schrøder, H.D.; Andersen, J.L.; Aagaard, P.; Schjerling, P.; Kjaer, M.

In: Journal of Physiology, Vol. 591, No. 15, 2013, p. 3789-3804.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Suetta, C, Frandsen, U, Mackey, A, Jensen, L, Hvid, LG, Bayer, ML, Petersson, SJ, Schrøder, HD, Andersen, JL, Aagaard, P, Schjerling, P & Kjaer, M 2013, 'Ageing is associated with diminished muscle re-growth and myogenic precursor cell expansion early after immobility-induced atrophy in human skeletal muscle', Journal of Physiology, vol. 591, no. 15, pp. 3789-3804. https://doi.org/10.1113/jphysiol.2013.257121

APA

Suetta, C., Frandsen, U., Mackey, A., Jensen, L., Hvid, L. G., Bayer, M. L., Petersson, S. J., Schrøder, H. D., Andersen, J. L., Aagaard, P., Schjerling, P., & Kjaer, M. (2013). Ageing is associated with diminished muscle re-growth and myogenic precursor cell expansion early after immobility-induced atrophy in human skeletal muscle. Journal of Physiology, 591(15), 3789-3804. https://doi.org/10.1113/jphysiol.2013.257121

Vancouver

Suetta C, Frandsen U, Mackey A, Jensen L, Hvid LG, Bayer ML et al. Ageing is associated with diminished muscle re-growth and myogenic precursor cell expansion early after immobility-induced atrophy in human skeletal muscle. Journal of Physiology. 2013;591(15):3789-3804. https://doi.org/10.1113/jphysiol.2013.257121

Author

Suetta, C. ; Frandsen, Ulrik ; Mackey, Abigail ; Jensen, L. ; Hvid, L. G. ; Bayer, M.L. ; Petersson, Stine Juhl ; Schrøder, H.D. ; Andersen, J.L. ; Aagaard, P. ; Schjerling, P. ; Kjaer, M. / Ageing is associated with diminished muscle re-growth and myogenic precursor cell expansion early after immobility-induced atrophy in human skeletal muscle. In: Journal of Physiology. 2013 ; Vol. 591, No. 15. pp. 3789-3804.

Bibtex

@article{944283502fc54d91929b876c6eb31a83,
title = "Ageing is associated with diminished muscle re-growth and myogenic precursor cell expansion early after immobility-induced atrophy in human skeletal muscle",
abstract = "Recovery of skeletal muscle mass from immobilisation-induced atrophy is faster in young than older individuals, yet the cellular mechanisms remain unknown. We examined the cellular and molecular regulation of muscle recovery in young and old human subjects subsequent to 2 weeks of immobility-induced muscle atrophy. Re-training consisted of 4 weeks of supervised resistive exercise in 9 older (OM: 67.3yrs, range 61-74) and 11 young (YM: 24.4yrs, range 21-30) males. Measures of myofiber area (MFA), Pax7-positive satellite cells (SC) associated with type I and type II muscle fibres, as well as gene expression analysis of key growth and transcription factors associated with local skeletal muscle milieu were performed after 2 weeks immobility (Imm) and following 3 days (+3d) and 4 weeks (+4wks) of re-training. OM demonstrated no detectable gains in MFA (VL muscle) and no increases in number of Pax7-positive SCs following 4 wks re-training, whereas YM increased their MFA (p",
author = "C. Suetta and Ulrik Frandsen and Abigail Mackey and L. Jensen and Hvid, {L. G.} and M.L. Bayer and Petersson, {Stine Juhl} and H.D. Schr{\o}der and J.L. Andersen and P. Aagaard and P. Schjerling and M. Kjaer",
year = "2013",
doi = "10.1113/jphysiol.2013.257121",
language = "English",
volume = "591",
pages = "3789--3804",
journal = "The Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",
number = "15",

}

RIS

TY - JOUR

T1 - Ageing is associated with diminished muscle re-growth and myogenic precursor cell expansion early after immobility-induced atrophy in human skeletal muscle

AU - Suetta, C.

AU - Frandsen, Ulrik

AU - Mackey, Abigail

AU - Jensen, L.

AU - Hvid, L. G.

AU - Bayer, M.L.

AU - Petersson, Stine Juhl

AU - Schrøder, H.D.

AU - Andersen, J.L.

AU - Aagaard, P.

AU - Schjerling, P.

AU - Kjaer, M.

PY - 2013

Y1 - 2013

N2 - Recovery of skeletal muscle mass from immobilisation-induced atrophy is faster in young than older individuals, yet the cellular mechanisms remain unknown. We examined the cellular and molecular regulation of muscle recovery in young and old human subjects subsequent to 2 weeks of immobility-induced muscle atrophy. Re-training consisted of 4 weeks of supervised resistive exercise in 9 older (OM: 67.3yrs, range 61-74) and 11 young (YM: 24.4yrs, range 21-30) males. Measures of myofiber area (MFA), Pax7-positive satellite cells (SC) associated with type I and type II muscle fibres, as well as gene expression analysis of key growth and transcription factors associated with local skeletal muscle milieu were performed after 2 weeks immobility (Imm) and following 3 days (+3d) and 4 weeks (+4wks) of re-training. OM demonstrated no detectable gains in MFA (VL muscle) and no increases in number of Pax7-positive SCs following 4 wks re-training, whereas YM increased their MFA (p

AB - Recovery of skeletal muscle mass from immobilisation-induced atrophy is faster in young than older individuals, yet the cellular mechanisms remain unknown. We examined the cellular and molecular regulation of muscle recovery in young and old human subjects subsequent to 2 weeks of immobility-induced muscle atrophy. Re-training consisted of 4 weeks of supervised resistive exercise in 9 older (OM: 67.3yrs, range 61-74) and 11 young (YM: 24.4yrs, range 21-30) males. Measures of myofiber area (MFA), Pax7-positive satellite cells (SC) associated with type I and type II muscle fibres, as well as gene expression analysis of key growth and transcription factors associated with local skeletal muscle milieu were performed after 2 weeks immobility (Imm) and following 3 days (+3d) and 4 weeks (+4wks) of re-training. OM demonstrated no detectable gains in MFA (VL muscle) and no increases in number of Pax7-positive SCs following 4 wks re-training, whereas YM increased their MFA (p

U2 - 10.1113/jphysiol.2013.257121

DO - 10.1113/jphysiol.2013.257121

M3 - Journal article

C2 - 23732643

VL - 591

SP - 3789

EP - 3804

JO - The Journal of Physiology

JF - The Journal of Physiology

SN - 0022-3751

IS - 15

ER -

ID: 47292119