Activation of interfacial enzymes at membrane surfaces
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Activation of interfacial enzymes at membrane surfaces. / Mouritsen, Ole G.; Andresen, Thomas L.; Halperin, Avi; Hansen, Per Lyngs; Jakobsen, Ask F.; Jensen, Uffe Bernchou; Jensen, Morten; Jørgensen, Kent; Kaasgaard, Thomas; Leidy, Chad; Simonsen, Adam Cohen; Peters, Günther H.; Weiss, Matthias.
In: Journal of Physics Condensed Matter, Vol. 18, No. 28, S12, 19.07.2006, p. S1293-S1304.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Activation of interfacial enzymes at membrane surfaces
AU - Mouritsen, Ole G.
AU - Andresen, Thomas L.
AU - Halperin, Avi
AU - Hansen, Per Lyngs
AU - Jakobsen, Ask F.
AU - Jensen, Uffe Bernchou
AU - Jensen, Morten
AU - Jørgensen, Kent
AU - Kaasgaard, Thomas
AU - Leidy, Chad
AU - Simonsen, Adam Cohen
AU - Peters, Günther H.
AU - Weiss, Matthias
PY - 2006/7/19
Y1 - 2006/7/19
N2 - A host of water-soluble enzymes are active at membrane surfaces and in association with membranes. Some of these enzymes are involved in signalling and in modification and remodelling of the membranes. A special class of enzymes, the phospholipases, and in particular secretory phospholipase A2 (sPLA2), are only activated at the interface between water and membrane surfaces, where they lead to a break-down of the lipid molecules into lysolipids and free fatty acids. The activation is critically dependent on the physical properties of the lipid-membrane substrate. A topical review is given of our current understanding of the physical mechanisms responsible for activation of sPLA2 as derived from a range of different experimental and theoretical investigations.
AB - A host of water-soluble enzymes are active at membrane surfaces and in association with membranes. Some of these enzymes are involved in signalling and in modification and remodelling of the membranes. A special class of enzymes, the phospholipases, and in particular secretory phospholipase A2 (sPLA2), are only activated at the interface between water and membrane surfaces, where they lead to a break-down of the lipid molecules into lysolipids and free fatty acids. The activation is critically dependent on the physical properties of the lipid-membrane substrate. A topical review is given of our current understanding of the physical mechanisms responsible for activation of sPLA2 as derived from a range of different experimental and theoretical investigations.
UR - http://www.scopus.com/inward/record.url?scp=33745625415&partnerID=8YFLogxK
U2 - 10.1088/0953-8984/18/28/S12
DO - 10.1088/0953-8984/18/28/S12
M3 - Journal article
AN - SCOPUS:33745625415
VL - 18
SP - S1293-S1304
JO - Journal of Physics: Condensed Matter
JF - Journal of Physics: Condensed Matter
SN - 0953-8984
IS - 28
M1 - S12
ER -
ID: 230978053