Acids ‘generally recognized as safe’ affect morphology and biocompatibility of electrospun chitosan/polyethylene oxide nanofibers

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Acids ‘generally recognized as safe’ affect morphology and biocompatibility of electrospun chitosan/polyethylene oxide nanofibers. / Stie, Mai Bay; Jones, Megan; Sørensen, Henning Osholm; Jacobsen, Jette; Chronakis, Ioannis S. ; Nielsen, Hanne Mørck.

In: Carbohydrate Polymers, Vol. 215, 01.07.2019, p. 253-262.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Stie, MB, Jones, M, Sørensen, HO, Jacobsen, J, Chronakis, IS & Nielsen, HM 2019, 'Acids ‘generally recognized as safe’ affect morphology and biocompatibility of electrospun chitosan/polyethylene oxide nanofibers', Carbohydrate Polymers, vol. 215, pp. 253-262. https://doi.org/10.1016/j.carbpol.2019.03.061

APA

Stie, M. B., Jones, M., Sørensen, H. O., Jacobsen, J., Chronakis, I. S., & Nielsen, H. M. (2019). Acids ‘generally recognized as safe’ affect morphology and biocompatibility of electrospun chitosan/polyethylene oxide nanofibers. Carbohydrate Polymers, 215, 253-262. https://doi.org/10.1016/j.carbpol.2019.03.061

Vancouver

Stie MB, Jones M, Sørensen HO, Jacobsen J, Chronakis IS, Nielsen HM. Acids ‘generally recognized as safe’ affect morphology and biocompatibility of electrospun chitosan/polyethylene oxide nanofibers. Carbohydrate Polymers. 2019 Jul 1;215:253-262. https://doi.org/10.1016/j.carbpol.2019.03.061

Author

Stie, Mai Bay ; Jones, Megan ; Sørensen, Henning Osholm ; Jacobsen, Jette ; Chronakis, Ioannis S. ; Nielsen, Hanne Mørck. / Acids ‘generally recognized as safe’ affect morphology and biocompatibility of electrospun chitosan/polyethylene oxide nanofibers. In: Carbohydrate Polymers. 2019 ; Vol. 215. pp. 253-262.

Bibtex

@article{08fde27c9d244e99a22417405be17438,

title = "Acids {\textquoteleft}generally recognized as safe{\textquoteright} affect morphology and biocompatibility of electrospun chitosan/polyethylene oxide nanofibers",

abstract = "Electrospinning of neat chitosan is currently achieved by using strong acids or organic solvents, which limits the use of chitosan nanofibers as biocompatible scaffolds for drug delivery and tissue engineering. The aim was to elucidate the effect of specific acids generally recognized as safe (GRAS) on the properties of electrospun chitosan-based nanofibers. Electrospinning chitosan in dilute acetic acid or succinic acid with polyethylene oxide resulted in white and separated nanofibers, whereas nanofibers electrospun in dilute citric acid were transparent and interconnected. Including succinic or citric acid in the spinning process induced disintegration of the fiber mat after four hours in water, and a concentration-dependent effect on epithelial cell viability. Chitosan nanofibers electrospun in acetic acid maintained their shape and fibrous structure after four hours in water, and showed no effect on cell viability. This study demonstrates that the choice of GRAS acid highly determines the properties of electrospun chitosan nanofibers.",

author = "Stie, {Mai Bay} and Megan Jones and S{\o}rensen, {Henning Osholm} and Jette Jacobsen and Chronakis, {Ioannis S.} and Nielsen, {Hanne M{\o}rck}",

year = "2019",

month = jul,

day = "1",

doi = "10.1016/j.carbpol.2019.03.061",

language = "English",

volume = "215",

pages = "253--262",

journal = "Carbohydrate Polymers",

issn = "0144-8617",

publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Acids ‘generally recognized as safe’ affect morphology and biocompatibility of electrospun chitosan/polyethylene oxide nanofibers

AU - Stie, Mai Bay

AU - Jones, Megan

AU - Sørensen, Henning Osholm

AU - Jacobsen, Jette

AU - Chronakis, Ioannis S.

AU - Nielsen, Hanne Mørck

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Electrospinning of neat chitosan is currently achieved by using strong acids or organic solvents, which limits the use of chitosan nanofibers as biocompatible scaffolds for drug delivery and tissue engineering. The aim was to elucidate the effect of specific acids generally recognized as safe (GRAS) on the properties of electrospun chitosan-based nanofibers. Electrospinning chitosan in dilute acetic acid or succinic acid with polyethylene oxide resulted in white and separated nanofibers, whereas nanofibers electrospun in dilute citric acid were transparent and interconnected. Including succinic or citric acid in the spinning process induced disintegration of the fiber mat after four hours in water, and a concentration-dependent effect on epithelial cell viability. Chitosan nanofibers electrospun in acetic acid maintained their shape and fibrous structure after four hours in water, and showed no effect on cell viability. This study demonstrates that the choice of GRAS acid highly determines the properties of electrospun chitosan nanofibers.

AB - Electrospinning of neat chitosan is currently achieved by using strong acids or organic solvents, which limits the use of chitosan nanofibers as biocompatible scaffolds for drug delivery and tissue engineering. The aim was to elucidate the effect of specific acids generally recognized as safe (GRAS) on the properties of electrospun chitosan-based nanofibers. Electrospinning chitosan in dilute acetic acid or succinic acid with polyethylene oxide resulted in white and separated nanofibers, whereas nanofibers electrospun in dilute citric acid were transparent and interconnected. Including succinic or citric acid in the spinning process induced disintegration of the fiber mat after four hours in water, and a concentration-dependent effect on epithelial cell viability. Chitosan nanofibers electrospun in acetic acid maintained their shape and fibrous structure after four hours in water, and showed no effect on cell viability. This study demonstrates that the choice of GRAS acid highly determines the properties of electrospun chitosan nanofibers.

U2 - 10.1016/j.carbpol.2019.03.061

DO - 10.1016/j.carbpol.2019.03.061

M3 - Journal article

C2 - 30981352

VL - 215

SP - 253

EP - 262

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

SN - 0144-8617

ER -

ID: 216310909