Accumulation of Disadvantages Across Multiple Domains Amongst Subgroups of Children of Parents with Schizophrenia or Bipolar Disorder: Clustering Data from the Danish High Risk and Resilience Study VIA 7
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Accumulation of Disadvantages Across Multiple Domains Amongst Subgroups of Children of Parents with Schizophrenia or Bipolar Disorder : Clustering Data from the Danish High Risk and Resilience Study VIA 7. / Krantz, Mette Falkenberg; Ellersgaard, Ditte; Andersen, Klaus Kaae; Hemager, Nicoline; Christiani, Camilla; Spang, Katrine Søborg; Burton, Birgitte Klee; Gregersen, Maja; Søndergaard, Anne; Greve, Aja; Gantriis, Ditte Lou; Ohland, Jessica; Mortensen, Preben Bo; Werge, Thomas; Nudel, Ron; Wang, Yunpeng; Hougaard, David M.; Plessen, Kerstin Jessica; Bliksted, Vibeke; Jepsen, Jens Richardt Møllegaard; Thorup, Anne A. E.; Mors, Ole; Nordentoft, Merete.
In: Schizophrenia Bulletin Open, Vol. 3, No. 1, sgac010, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Accumulation of Disadvantages Across Multiple Domains Amongst Subgroups of Children of Parents with Schizophrenia or Bipolar Disorder
T2 - Clustering Data from the Danish High Risk and Resilience Study VIA 7
AU - Krantz, Mette Falkenberg
AU - Ellersgaard, Ditte
AU - Andersen, Klaus Kaae
AU - Hemager, Nicoline
AU - Christiani, Camilla
AU - Spang, Katrine Søborg
AU - Burton, Birgitte Klee
AU - Gregersen, Maja
AU - Søndergaard, Anne
AU - Greve, Aja
AU - Gantriis, Ditte Lou
AU - Ohland, Jessica
AU - Mortensen, Preben Bo
AU - Werge, Thomas
AU - Nudel, Ron
AU - Wang, Yunpeng
AU - Hougaard, David M.
AU - Plessen, Kerstin Jessica
AU - Bliksted, Vibeke
AU - Jepsen, Jens Richardt Møllegaard
AU - Thorup, Anne A. E.
AU - Mors, Ole
AU - Nordentoft, Merete
N1 - Publisher Copyright: © 2022 The Author(s) 2022. Published by Oxford University Press on behalf of the University of Maryland's school of medicine, Maryland Psychiatric Research Center.
PY - 2022
Y1 - 2022
N2 - Objective: Children with familial high-risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) are frequently affected in a range of domains known to be precursors of severe mental illness. No previous studies have gathered known precursors to examine whether they distribute evenly across familial high risk (FHR) children or if they cluster among a smaller group. Since such examination holds the potential to identify high and low risk of severe mental illness groups, we aimed to cluster FHR and control children affected to various degrees. Method: In The Danish High Risk and Resilience Study VIA 7, a clinical cohort study, 514 7-year-old children with FHR-SZ or FHR-BP and matched controls were assessed in domains of motor function, neurocognition, emotional control, behavior, social cognition, self-perception, language, psychotic experiences, and psychopathology, and grouped using cluster analysis. Associations between clusters and parents' level of education, functioning, caregiver status, child's level of stimulation and support in the home, and polygenic risk scores were examined. Results: A total of four groups including one of broadly affected children were identified. The broadly affected group was represented 4-5-fold (18.1%) amongst FHR-SZ children and 2-3-fold (10.2%) amongst FHR-BP children, compared to controls (4.1%) (P <. 001), and the broadly affected group had lower levels of caregiver functioning (P <. 001) and stimulation and support at home (P <. 001). Conclusion: Precursors of severe mental illness distribute unevenly among FHR children; while approximately half are not affected in any domains, the other half are affected to various degrees. Targeted support towards the affected groups is indicated.
AB - Objective: Children with familial high-risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) are frequently affected in a range of domains known to be precursors of severe mental illness. No previous studies have gathered known precursors to examine whether they distribute evenly across familial high risk (FHR) children or if they cluster among a smaller group. Since such examination holds the potential to identify high and low risk of severe mental illness groups, we aimed to cluster FHR and control children affected to various degrees. Method: In The Danish High Risk and Resilience Study VIA 7, a clinical cohort study, 514 7-year-old children with FHR-SZ or FHR-BP and matched controls were assessed in domains of motor function, neurocognition, emotional control, behavior, social cognition, self-perception, language, psychotic experiences, and psychopathology, and grouped using cluster analysis. Associations between clusters and parents' level of education, functioning, caregiver status, child's level of stimulation and support in the home, and polygenic risk scores were examined. Results: A total of four groups including one of broadly affected children were identified. The broadly affected group was represented 4-5-fold (18.1%) amongst FHR-SZ children and 2-3-fold (10.2%) amongst FHR-BP children, compared to controls (4.1%) (P <. 001), and the broadly affected group had lower levels of caregiver functioning (P <. 001) and stimulation and support at home (P <. 001). Conclusion: Precursors of severe mental illness distribute unevenly among FHR children; while approximately half are not affected in any domains, the other half are affected to various degrees. Targeted support towards the affected groups is indicated.
KW - bipolar disorder
KW - cross-domain
KW - distribution
KW - familial high-risk
KW - schizophrenia
U2 - 10.1093/schizbullopen/sgac010
DO - 10.1093/schizbullopen/sgac010
M3 - Journal article
AN - SCOPUS:85132981873
VL - 3
JO - Schizophrenia Bulletin Open
JF - Schizophrenia Bulletin Open
SN - 2632-7899
IS - 1
M1 - sgac010
ER -
ID: 324555463